Journal Reviews
Updated staging of LCHADD retinopathy
The authors present their proposal for an updated staging system for Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) deficiency retinopathy. This is a rare mitochondrial disease due to deficiency of the long chain fatty acid oxidation pathway. Forty patients who were part of...
Outcomes following repair of early-onset versus delayed-onset rhegmatogenous retinal detachments (RD) after acute posterior vitreous detachment (PVD)
This is a retrospective single centre comparative interventional study of 210 patients in total, between 2015 to 2020, presenting with delayed RD (diagnosed >42 days after initial acute PVD presentation) compared with a 2:1 age and gender-matched acute RD cohort...
Stargardt disease in a Turkish cohort
The authors present a study of 27 Turkish patients who were seen in a single centre over a five-year period. All patients had macular optical coherence tomography (OCT), colour fundus photography and 30-2 Humphery visual fields performed, along with clinical...
IVTA for diabetic macular edema and macular edema secondary to retinal vein occlusion: a meta-analysis
This meta-analysis aimed to compare the safety and efficacy of different doses of intravitreal triamcinolone acetonide (IVTA) for diabetic macular oedema (DME) and macular oedema (ME) secondary to retinal vein occlusion (RVO). A systematic literature search for randomised controlled trials...
Comprehensive review of inherited retinal diseases
The authors offer an up-to-date review of inherited retinal diseases (IRDs). In each section the authors discuss the molecular basis of disease, genotype and clinical manifestation. They also discuss the investigation findings and current evidence in the treatment of the...
Contrast sensitivity in myopic eyes
A classification system has been proposed for myopic maculopathy: grade 0 (no myopic retinal lesions), grade 1 (tessellated fundus), grade 2 (diffuse chorioretinal atrophy (CRA)), grade 3 (patchy CRA), and grade 4 (macular atrophy). Tessellated fundus is defined as the...
Persistent subretinal fluid (PSFF) in pneumatic retinopexy (PNR) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD): posthoc analysis of the PIVOT randomised trial
This is a posthoc study of the PIVOT randomised trial over a 12 month period, to evaluate the functional outcomes of the incidence of PSF in PnR versus PPV following RRD surgery. One hundred and fifty-eight patients were recruited and...
OCTA in diabetic macular oedema treated with intravitreal aflibercept (DOCTA Study)
Central vision loss due to diabetic macular oedema (DME) can be attributed not only to presence of the macular oedema itself but also, in some cases, to alterations of the foveal avascular zone (FAZ). The DOCTA trial was a longitudinal,...
All you need to know about PIC
This is a review article of punctate inner chorioretinopathy (PIC). The authors detail the epidemiology and clinic presentation of the disease. They recognise the challenge of an accurate diagnosis due to its resemblance to other posterior uveitic entities. Multimodal imaging...
The compendium to clinical evidence in DMO treatment
This review article summarises the current evidence base in the treatment options for diabetic macular oedema (DMO). The authors have included many real-world data studies that provided valuable insights into the optimal management of DMO. The authors argue that these...
Macular pigment in relatives of AMD patients
Blue light causes photo-oxidative retinal injury and macular pigment (MP), with lutein, zeaxanthin and mesozeaxanthin as the main components, as a filter that protects the macula from this damage. Previous studies indicated that low levels of macular pigment optical density...
The potential of artificial intelligence and digital health in global eye health
This article provides an overview of the current landscape of artificial intelligence (AI) and digital health in global eye health. Tan, et al. note that though significant progress has been made in global eye health over the last few decades,...
