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Journal Reviews

Does intravitreal bevacizumab help in diabetic retinopathy related vitreous haemorrhage?

1 October 2017 | Efrosini Papagiannuli | EYE - Vitreo-Retinal

This retrospective, interventional case series, aimed to assess the effectiveness of intravitreal bevacizumab (IVB) in vitreous haemorrhage secondary to proliferative diabetic retinopathy. The primary outcome was the rate of vitrectomy (PPV) after IVB, with secondary outcomes the number of IVB...

Fingolimod: ocular adverse effects

1 October 2017 | Sofia Rokerya | EYE - Vitreo-Retinal

In this article the authors review the ocular side-effects of Fingolimod which is an oral immunomodulating drug used in the management of relapsing-remitting multiple sclerosis (RRMS). Fingolimod-associated macular oedema (FAME) is the most common ocular side-effect linked to this drug....

Importing iron to the retina

1 October 2017 | Graham Wallace | EYE - Vitreo-Retinal

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

Retinitis pigmentosa (RP) associated cystoid macular oedema (CMO)

1 October 2017 | Jonathan Chan | EYE - Vitreo-Retinal

This is a review article from two units in the UK and Australia, highlighting the supporting evidence of possible pathogenesis and treatment modalities of CMO in RP. The authors proposed that the likely mechanisms for RP-CMO involved the breakdown of...

A possible biomarker for diabetic retinopathy

1 August 2017 | Graham Wallace | EYE - Vitreo-Retinal

Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...

A standardised strategy for uveitis etiological diagnosis

1 August 2017 | Efrosini Papagiannuli | EYE - Vitreo-Retinal

This was a prospective, non-inferiority, multicentre randomised control trial, which aimed to assess the effectiveness of a standardised approach in the etiological diagnosis of uveitis versus an open strategy, where clinicians could perform any test. The authors developed their standardised...

OCT angiography in PAMM secondary to CRVO

1 June 2017 | Sofia Rokerya | EYE - Vitreo-Retinal

Paracentral acute middle maculopathy (PAMM) is a recently described manifestation presenting with hyperreflective bands within mid retina on spectral domain optical coherence tomography (SD OCT). The current view is that these findings are markers of ischaemia of deep retinal circulation....

Finasteride and central serous chorioretinopathy

1 June 2017 | Sofia Rokerya | EYE - Vitreo-Retinal

The pathophysiology of central serous chorioretinopathy (CSC) is complex and has not been fully elucidated. Suggested theories include hyperpermeability and increased hydrostatic pressure in the choroidal vasculature, which creates RPE detachments overwhelming the RPE barrier function, leading to accumulation of...

HLA-B27 anterior uveitis

1 June 2017 | Saruban Pasu | EYE - Vitreo-Retinal

HLA-B27 has previously been shown to have an association with uveitis, ankylosing spondylitis, reactive arthritis, ulcerative colitis and psoriasis. The authors of this review provide an update of the epidemiology of HLA-B27 associated ocular disorders. There is great variation amongst...

How many injections in nAMD: ranibizumab vs. aflibercept

1 April 2017 | Eulee Seow | EYE - Vitreo-Retinal

Intravitreal anti-VEGF injections make up a large proportion of the workload in ophthalmology clinics. Since the introduction of aflibercept with eight weekly injections there has been an option to use a treatment which may require less treatment, with potential cost...

Vitrectomy after ocriplasmin for VVMT adhesion of MH study

1 April 2017 | Jonathan Chan | EYE - Vitreo-Retinal

This is a multicentre retrospective study of 51 eyes that received intravitreal ocriplasmin between January 2013 to January 2014 for symptomatic vitreomacular (VMT) +/- macular hole (MH), and then went on to PPV for persistent pathology, comparing a control group...

Treat and extend for PCV

1 April 2017 | Saruban Pasu | EYE - Vitreo-Retinal

This South Korean study investigated the efficacy of a treat and extend regimen (TER) using ranibizumab to treat polypoidal choroidal vasculopathy (PCV). Twenty-nine eyes were included in this retrospective case note review. Of these, five eyes had been treated with...

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