Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)
1 October 2018
| Kurt Spiteri Cornish
|
EYE - Vitreo-Retinal
The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...
Macular atrophy with aflibercept
1 October 2018
| Saruban Pasu
|
EYE - Vitreo-Retinal
The authors of this paper set out to investigate the prevalence of macular atrophy in treatment-naive patients with neovascular AMD undergoing aflibercept monotherapy (three monthly loading injections followed by subsequent treatment every two months). Case notes over a three year...
Meta-analysis of HLA B27 associated acute anterior uveitis
1 August 2018
| Mrinal Rana
|
EYE - Vitreo-Retinal
A literature-based meta-analysis was carried out to look at the various clinical features associated with HLA- B27 acute anterior uveitis (AAU). After an extensive search of literature for HLA B27 uveitis was conducted, 735 results were obtained. Twenty-nine articles were...
Automated grading of diabetic retinopathy: is it possible?
1 August 2018
| Eulee Seow
|
EYE - Vitreo-Retinal
Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a leading cause of blindness worldwide. However, much of this diabetic blindness can be delayed or even prevented with timely diagnosis and proper treatment. For this reason, regular screening...
International variations in ROP treatment
1 August 2018
| Jonathan Chan
|
EYE - Vitreo-Retinal
A retrospective cohort review of 48,087 premature infants weighing <1500 gm between 24 to 27 weeks gestation, from 11 high income countries in Australia, New Zealand, Canada, Finland, Israel, Japan, Spain, Sweden, Switzerland, Tuscany (Italy) and the UK . By...
The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy
1 August 2018
| Kurt Spiteri Cornish
|
EYE - Vitreo-Retinal
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...
CD40L activation of human RPE cells
1 August 2018
| Graham Wallace
|
EYE - Vitreo-Retinal
Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...
Diagnosis of ocular tuberculosis
1 August 2018
| Nikolaos D Georgakarakos
|
EYE - Vitreo-Retinal
This review article provides an update on the methods diagnosing ocular tuberculosis (TB), the difficulties in making the diagnosis and makes recommendations to a more accurate diagnosis by combining the available diagnostic tests. Today ocular TB remains a presumptive clinical...
Medical malpractice in uveitis: a review of clinical entities and outcomes
1 August 2018
| Nikolaos D Georgakarakos
|
EYE - Vitreo-Retinal
This paper presents a retrospective review of malpractice verdicts, rulings and settlements in the United States. Twenty-five cases of uveitis-related litigation spanning 1971-2014 were identified from the database representing 2.3% of all cases. Forty-eight percent of the cases were infectious....
ABCA1 mediates lipid efflux in the retina
1 June 2018
| Graham Wallace
|
EYE - Vitreo-Retinal
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. There are two forms of AMD, dry and wet, the latter so named because of the presence of choroidal neovascularisation. Both forms lead to retinal pigment...
ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
1 June 2018
| Graham Wallace
|
EYE - Vitreo-Retinal
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
OCTA use in CNV associated with CSR
1 June 2018
| Saruban Pasu
|
EYE - Vitreo-Retinal
The aim of this study was to assess the rate of choroidal neovascularisation (CNV) in chronic central serous chorioretinopathy (CSR) patients with flat irregular pigment epithelial detachments (PEDs) by optical coherence tomography angiography (OCTA). Data of all consecutive patients with...
