Journal Reviews
Healthcare costs of early vs late genetic testing
This is a retrospective observational cohort study of the relative healthcare costs incurred by early vs late genetic testing for inherited retinal diseases in a population of patients from the USA. Three hundred and ten patients with a genetically confirmed...
Elevated anxiety levels in central serous chorioretinopathy
This prospective cross-sectional case-control, questionnaire-based study was aimed to compare association of anxiety disorder in patients with central serous chorioretinopathy (CSCR) and age-gender-matched healthy controls. Participants in the age group of 18–55 years were divided into 2 groups. Group A...
Open globe trauma – visual outcomes after primary vitrectomy
This retrospective study aimed to evaluate the impact of early vitrectomy on visual outcomes in eyes with open globe ocular trauma. One hundred and eighty eyes from a cohort of 166 patients who underwent primary vitrectomy between 2017 and 2023...
Reclassifying genetic variants in inherited retinal diseases
The authors present a retrospective study of 142 gene sequence variants from 28 patients with vitreoretinal dystrophies which were re-interpreted based on American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines. Overall, there was...
Clinical characteristics and visual outcome of patients with macular pseudohole
This is a retrospective study of consecutive patients with macular pseudohole (MPH) who had vitrectomy and were followed for at least 6 months postoperatively. MPH was diagnosed based on spectral-domain optical coherence tomography (OCT) findings. 76 eyes of 75 patients...
Patient perspectives on inherited retinal diseases
The authors present a qualitative study of patient perspectives on living with inherited retinal diseases based on social media engagement. Social media posts from 6 sites were analysed over a 10-year period. Data was extracted manually by the research team,...
Comparison of the efficacy of anti-VEGFs agents in nvAMD
This retrospective multicentric study conducted in Israel and Canada, compared the efficacy of bevacizumab, aflibercept 2mg and ranibizumab as first-line treatments for neovascular age-related macular degeneration (nvAMD). Included were treatment-naïve nvAMD eyes receiving ≥12 months of treat-and-extend (T&E) anti-VEGF therapy...
Fenofibrate and diabetic retinopathy
Fenofibrate is an agonist of peroxisome proliferator-activated receptor-alpha (PPARα) which is used as a lipid-lowering agent. By reducing blood lipid levels, it can decrease retinal hard exudates which is beneficial in diabetic retinopathy (DR). FIELD and ACCORD studies show that...
IVT Aflibercept 2mg in nAMD: XTEND at 3 years
This study investigated the long-term, effectiveness and safety of IVT-AFL 2mg for neovascular age-related macular degeneration (nAMD). XTEND was a multicentre, observational, prospective study, which was conducted across 127 centres across 17 countries with a follow-up period of 36 months....
ILM peeling in proliferative diabetic retinopathy: a meta-analysis
This meta-analysis highlights the efficacy of internal limiting membrane (ILM) peeling on treating posterior segment complications other than macular oedema in patients with proliferative diabetic retinopathy (PDR) treated with vitrectomy. PubMed, EMBASE and Cochrane Library were searched for databases. Eleven...
Usher syndrome patient reported outcomes
The authors present a systematic review of the literature on patient-reported outcomes in Usher syndrome; a leading cause of deaf-blindness. A total of 27 studies were included, and there was a strong bias towards studies from the US and Europe...
Anti-VEGF injections and macular atrophy progression in patients with nAMD in remission
This is a retrospective study of 59 eyes with neovascuar age-related macular degeneration (nAMD) with at least 6-month remission, to determine the effect of continuing anti-VEGF injections on the progression of macular atrophy (MA) during remission of nAMD. Group 1...
