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Effect of selenium and vitamin E supplements on the development and progression of cataracts
The Selenium and Vitamin E Cancer Prevention Trial (SELECT) investigated the influence of dietary supplements on the development of prostate cancer in a group of 35,533 middle aged and older, apparently healthy men. The SELECT Eye Endpoint (SEE) study is...
Surgical management of high myopia strabismus
This is a small case series of three patients with unilateral or bilateral high myopia with exotropia and hypotropia. Surgery involved nasal loop myopexy between the medial and superior recti muscles with or without lateral rectus recession and / or...
Superior oblique sagittalisation
This paper reports two cases with anomalous posterior course of the superior oblique tendon with insertion nasal to the superior rectus tendon. Both presented with Brown syndrome-like clinical scenarios. The cases were a five-year-old female and four-year-old male. Diagnosis was...
Success rates of primary and revision transcanalicular DCR surgery
Transcanalicular laser DCR is a relatively rare procedure compared to more conventional external or endo-nasal techniques. In this article the authors examine the outcomes of revision surgery following failed transcanalicular diode laser dacryocystorhinostomy (TCDL DCR), comparing a conventional external revision...FAQs about cerebral visual impairment (CVI): identifying and helping those affected
Cerebral visual impairment is common in both adults and children, yet the diagnosis can easily be missed unless one is tuned into the presenting features. This article provides a succinct introduction to this important topic. What is vision? Vision is...
Randomised trial of multifocal intraocular lens versus monovision
The authors report on a randomised, multicentre clinical trial comparing the outcomes of Tecnis ZM900 diffractive multifocal intraocular lenses (IOL) versus monovision with Akreos AO monofocal IOL (dominant eye targeted for emmetropia and non-dominant eye targeted for -1 to -1.50...
New prognostic model for multiple sclerosis after optic neuritis presentation
The authors present a post-hoc analysis using the publicly available data set from the Optic Neuritis Treatment Trial. The Cox proportional hazards regression models were used to assess for associations between clinical and radiological variables and the development of clinical...
Systemic anti-inflammatory versus fluocinolone acetonide intraocular implant
In the Multicenter Uveitis Steroid Treatment (MUST) trial, 255 patients with intermediate uveitis, posterior uveitis or panuveitis were randomised to either fluocinolone acetonide intraocular implant or systemic corticosteroid therapy which was supplemented with immunosuppression if required. Patients were followed up...
CD73 in aggressive basal cell carcinoma
This is a retrospective review looking at levels of CD73 in aggressive basal cell carcinomas (BCCs) that invade the orbit. Eleven patients who underwent orbital exenteration for invasion by BCCs were compared with 10 matched controls who had simple nodular...
Sebaceous gland carcinoma
This is a review of 241 patients diagnosed with periocular sebaceous gland carcinoma which investigates whether age at presentation influences either the clinical presentation or the outcomes of treatment. Twelve percent of patients were classified as young (<40 years old),...
Therapeutic options for advanced cutaneous basal (BCC) and squamous cell carcinomas (SCC)
This article discusses the use of topical and systemic therapy in the management of advanced periocular tumours. It focuses on those that have gained United States Food and Drug Administration approval; namely imiquimod, vismodegib, sonidegib, pembrolizumab and cemiplimab. Imiquimod is...
