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110 results found

Differential diagnosis of inflammatory optic neuritis

The authors present the differential diagnosis of inflammatory optic neuritis (ON) to include multiple sclerosis, infectious optic neuritis, systemic disease and neuromyelitis optica (NMO). The features of ON for the varying aetiologies are detailed including incidence and overlap. In acute...

Typical and atypical optic neuritis – diagnosis and initial management

Optic neuritis is a relatively common presentation to ophthalmologists in the acute setting. The vast majority are cases of ‘typical’ optic neuritis (ON) but a smaller group of conditions, so-called, ‘atypical’ optic neuritides require a different work-up and management strategy....

ROPPVAL Syndrome as a differential diagnosis to optic neuritis

Optic neuritis (ON) is a common cause of visual loss in young patients. Patients with eye pain and ipsilateral visual loss are often referred into neuro-ophthalmology clinics with a possible diagnosis of ON. In 2018 Jefferis et al. reported a...

Long-term retinal changes following unilateral retrobulbar optic neuritis

The aim of this study was to assess the longitudinal changes in retinal nerve fibre layer (RNFL) thickness after a first attack of optic neuritis and to investigate the impact of treatment on RNFL thinning at one year after the...

Correlation between structural and functional status of optic nerve and retina in multiple sclerosis

Multiple sclerosis (MS) involves autoimmune inflammatory demyelination and axonal degeneration in the central nervous system. Investigation of the retina and optic nerve head (ONH) is an ideal way to visualise this demyelination. This study investigates the functional and structural properties...

Mechanism of colour vision involvement in multiple sclerosis

There is evidence to show that the optic nerve and retina are affected in multiple sclerosis (MS) even without any clinical evidence or history of optic neuritis (ON). MS without optic neuritis causes colour-vision deficit, however, the evidence for selective...

MRI characteristics of NMO, MOG and MS-related ON

This review article examined differences of MRI appearances that can help clinicians assess and manage these important neuro-ophthalmic disorders. It also examined the role of optic nerve MRI as a prognostic indicator in acute optic neuritis (ON). The major findings...

Two illustrative cases of AZOOR

The authors present two illustrative cases of acute zonal occult outer retinopathy (AZOOR) which causes acute idiopathic blind spot enlargement. The disease is characterised by sudden loss of outer retinal function associated with photopsia, with minimal or no fundoscopic changes...

Comparison of two visual acuity test versions for different distances in a paediatric population

The authors present the findings of a study which aimed to determine whether using 2 metre and 4 metre retro-illuminated ETDRS charts are comparable in children. Order of testing was standardised (right eye, left eye, binocular), however different charts were...

Validity of coding in neuro-ophthalmology within large administrative datasets

A systematic review of validation studies of the International Classification of Disease (ICD) coding system, ICD-9 and ICD-10 is presented by the authors. Three searches were conducted based on three concepts, firstly health administration claims and ICD codes, secondly diagnostic...

Investigating MOG-IgG as a cause for optic perineuritis

Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but in most cases is considered idiopathic. Diagnosis is established by magnetic resonance imaging (MRI) with the demonstration of optic nerve sheath enhancement with sparing of the optic...

The ophthalmologist’s elbow: a potentially painful point of contact

Three months ago I leant, in the customary manner, on the box of my indirect lens at the slit lamp to examine a patient’s fundus. An acute and severe pain in the tip of my elbow immediately interrupted me. I...