Anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis: a retrospective medical records review
Reviewed by Claire Howard

Optic neuritis causes acute loss of visual function and can result in devastating visual dysfunction. Recently, measurements of anti-aquaporin 4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have become available, making it possible to evaluate the disease pathogenesis. This paper reviews the clinical features of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis (MOGON), using a retrospective medical record review. The authors report the clinical characteristics, visual function, optical coherence tomography findings, and magnetic resonance imaging of 31 patients (44 eyes). Anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis was more common in middle age without sex difference and was characterised by pain on eye movement and optic disc swelling. Magnetic resonance imaging lesions tended to be long with inflammation around the optic nerve sheath; longer lesions were associated with worse visual acuities at onset. Recurrence was significantly associated with retinal nerve fibre layer thinning, and thus, it is important to reduce recurrence as much as possible. This study gives a small sample retrospective overview, however larger sample prospective randomised controlled trials are required to better understand the clinical features of MOGON.

Clinical features and prognostic factors in anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis.
Takai Y, Yamagami A, Iwasa M, et al.
NEURO-OPHTHALMOLOGY
2024;48(2):134–41.