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Methotrexate and mycophenolate mofetil for non-infectious uveitis

This is the first reported randomised clinical trial comparing methotrexate versus mycophenolate mofetil (MMF) for the treatment of non-infectious intermediate uveitis, posterior uveitis or panuveitis. To be eligible for recruitment, patients had to be on ≥15mg oral prednisone and demonstrated...

Meibomian gland dropout in patients with dry eyes

In this prospective study 264 patients with symptoms of dry eye were examined with a non-contact meibography system to assess the morphological changes in their meibomian glands. These patients were not previously diagnosed with meibomian gland dysfunction and patients with...

RPE use similar pathway to regulatory T cells to inhibit immune response

Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....

Binocular training for amblyopia

The clinical effectiveness of binocular investigation for amblyopia was measured. The authors had previously unsuccessfully treated patients using occlusion and / or surgery. Patients were followed for an average of six months after cessation of treatment. The study included 22...

Phakic iris clip lenses and endothelial cell loss

This retrospective observational study included long-term results on endothelial cell losses in highly myopic eyes, which underwent phakic iris-clip lens implantations. Included in the analysis were 113 eyes with mean preoperative spherical equivalent (SEQ) of -14.67 +/- 5.15 Diopters (D)....

A case of post-viral ocular microflutter

A number of eye movements disrupt visual fixation, one such movement being saccadic intrusions which are described as small involuntary saccadic movements. Among saccadic intrusions without intersaccadic intervals, ocular flutter and opsoclonus are prominent. When the saccadic amplitude is very...

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Success rates of primary and revision transcanalicular DCR surgery

Transcanalicular laser DCR is a relatively rare procedure compared to more conventional external or endo-nasal techniques. In this article the authors examine the outcomes of revision surgery following failed transcanalicular diode laser dacryocystorhinostomy (TCDL DCR), comparing a conventional external revision...

The prevalence of macular cysts in patients with clinical cone-rod dystrophy determined by spectral domain optical coherence tomography

Cone-rod dystrophy is a progressive photoreceptor disorder which has multiple inheritance patterns. It is rare, with a prevalence of 1 in 40,000. Macular cysts are well recognised in other photoreceptor conditions such as retinitis pigments and choroideraemia, while they are...

SLT short-term results

The aim of the study was to evaluate the risk of adverse effects and short-term results after 360 degrees selective laser trabeculoplasty (SLT) in glaucoma patients. The authors enrolled 64 eyes of 64 patients all who had poorly controlled primary...

Risk factors for failed vision screening

Failure rates on vision screening tests were reported by age and racial / ethnic categories in a large sample of children with most aged 6-11 years. Many children resided in lower socioeconomic status areas. Data was taken from 9743 children....

Management of high AC/A esotropia

The purpose of this study was to determine the long-term effect of treating high accommodative convergence to accommodation (AC/A) esotropia with single vision lenses (SVL) compared with the effectiveness of using SVL on patients with basic refractive esotropia and a...