The aim of the study was to evaluate the risk of adverse effects and short-term results after 360 degrees selective laser trabeculoplasty (SLT) in glaucoma patients. The authors enrolled 64 eyes of 64 patients all who had poorly controlled primary open-angle glaucoma (POAG) by medical treatment. Patients were assessed for inflammation in the anterior chamber, inflammatory signs in the vitreous and retina intraocular pressure (IOP), both before and after SLT at 24hrs, 14 days, six weeks and three months after laser. The retinal thickness was assessed using spectralis OCT. All SLT procedures were performed by the same experienced surgeon and grading of inflammation, IOP measurement and OCT scanning were conducted by another examiner independently. All patients were treated with SLT for the first time and the authors showed a statistically significant reduction in mean IOP at each interval. There was no statistically significant increase in mean retinal thickness and there were no clinically relevant signs of inflammation in the anterior chamber or vitreous. The authors’ results showed that 360 degree SLT treatment produced no clinically relevant inflammation and the authors did not use any pre or postoperative medications which they believe is the first study to investigate this. Limitations of the study include the missing of post treatment IOP spikes within the first 24hrs. The authors conclude that further similar studies need to be conducted in patients with pseudoexfoliation or pigmentary glaucoma following SLT.