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Mast cells in Graves’ ophthalmopathy
Graves’ ophthalmopathy (GO) is a potentially sight-threatening ocular disease, occurring in patients with hyperthyroidism due to Graves’ disease. Also known as thyroid-associated ophthalmopathy, GO is characterised by orbital infiltration by immune cells including macrophages, T cells and plasma cells, which...
Topical cyclosporine A 0.05% for recurrent anterior uveitis
This is a retrospective case-crossover study conducted by reviewing medical charts of patients treated for recurrent anterior uveitis between 2002 and 2011 at the Kellogg Eye Centre by one cornea specialist. The demographics, episodes of anterior uveitis, severity of episodes...
Aspheric toric IOL implantation and LRI in eyes with cataracts and astigmatism
This is a prospective study from a single unit to compare the visual outcome of aspheric toric intraocular lens (IOL) implantation and limbal relaxing incisions (LRI) for management of coexisting age-related cataracts and astigmatism. Sixty eyes of 60 patients with...
Bupivicaine injection for Bell’s palsy
This study assesses the use of intramuscular bupivicaine to treat lid retraction and lagophthalmos in facial palsy. It is a prospective non-comparative interventional series of 10 patients with Bell’s palsy (House-Brackman grade IV or V) who each received three serial...
RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
Revision of orbital fracture repairs
This is a retrospective review of 13 patients with sub-optimal outcomes following primary orbital fracture repairs who underwent revision surgery. All had fractures of the orbital floor, with four involving other orbital walls, and six also involving other facial bones....
Platelet-rich fibrin for conjunctivoplasty after pterygium excision
The authors report a prospective, comparative, non-randomized clinical trial of 35 pterygium patients with unilateral nasal primary pterygium infiltrating the cornea 2-5mm in size, who underwent pterygium excision between June 2013 and September 2014. Thirty-five eyes of 35 patients with...
Persistence of Ebola virus in ocular fluid during convalescence
The most recent Ebola outbreak has infected over 26,300 patients, but also resulted in the highest number of survivors in history. Uveitis has been described during the convalescent period, but Varkey and colleagues report, for the first time, finding viable...
Oral omega-3 fatty acid treatment for dry eye in contact lens wearers
This study evaluates the effect of dietary omega-3 fatty acid supplementation of dry eye symptoms, tear film tests, and conjunctival impression cytology in patients with contact lens wear-associated dry eye. In this randomised double-blind, multi-centred trial, contact lens wearers (n=...
Effect of anti-VEGF treatment on PED morphology
This retrospective study of 30 eyes assessed the effect of anti-VEGF on morphology of pigment epithelial detachments (PED) secondary to age-related macular degeneration (AMD). Thirty eyes of 28 patients with PED were compared to 30 eyes of 30 patients with...
Better outcomes from early repair of Type B blow-out fractures
This paper examines whether early, rather than late, surgical repair results in better motility outcomes for a particular subgroup of orbital floor blowout fractures. The authors divide floor fractures into Types A and B, depending on whether or not the...
