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RCT of IOL type
The optical performance of pseudophakic eyes were compared after implantation of spherical and aspheric IOLs in paediatric patients after cataract surgery. This randomised controlled trial included 40 eyes of 23 patients: 20 eyes in each group. Follow-up was over three...
Diabetic polyneuropathy and risk of developing diabetic retinopathy
Diabetic polyneuropathy (DPN), diabetic retinopathy (DR) and diabetic nephropathy are widely classified as microvascular complications of diabetes. DPN, which may cause complete sensation loss, is another common complication of DM. The DPN-related diminished sensation presents a significant risk factor for...
Genetic analysis of choroideremia families
Choroideremia (CHM) is a rare X linked recessive chorioretinal dystrophy. Symptoms include nyctalopia and progressive peripheral field loss. Female carriers may have mild symptoms. Choroideremia is known to be caused by a mutation in the CHM gene. A multicentre human...
Ozurdex wound leakage
This letter to the editor describes two cases of wound leakage after Ozurdex injection. The first case is a man who had four previous injections for an underlying diagnosis of chronic serpiginous choroiditis, who was also on a course of...
PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Limbal melanocytes and the stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
A case report of alternating anisocoria with associated nasal congestion
The authors have described a group of healthy individuals who show alternating anisocoria, in a previous paper. In these cases, the pupil asymmetry alternates between eyes every few hours, with no observed instances when both pupils are equal in size....
Could medical cannabis be used to successfully treat blepharospam?
This study observed the effect of medical cannabis in benign essential blepharospasm (BEB), in addition to standard botulinum toxin treatment. The study comprised of a retrospective chart review on eligible patients and included information on patient demographics, responses, cannabis history...
Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)
The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...
