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324 results found

Prostaglandin-associated periorbitopathy

This is a masked study of 33 patients who had been taking a prostaglandin analogue in one eye only for at least a year, to look for signs of prostaglandin-associated periorbitopathy (PAP). The investigators devised a new grading system to...

Combined anti-VEGF and PDT for wet AMD

The authors report on a retrospective case series of combined anti-VEGF and photodynamic therapy (PDT) in the treatment of wet age-related macular degeneration (AMD) refractory to anti-VEGF monotherapy alone. The criteria for treatment failure of anti-VEGF monotherapy were persistent subretinal...

Use of pattern-reversal VEP in congenital Zika syndrome (CZS) assessment

The authors conducted pattern reversal visual evoked potential (PRVEP) in children with congenital Zika syndrome (CZS) and report the correlates with visual acuity, fundus alterations and severity of microcephaly at birth. This was a cross-sectional study of 37 children with...

Leber’s hereditary optic neuropathy outcomes in an Indian population

A large cohort study in an Indian population is presented, with clinical and genetic profile analysis of patients with Leber’s hereditary optic neuropathy (LHON) treated over a five-year period. The study included 157 patients; 143 male, 14 female (10.2:1 ratio)...

FEVR characteristics

The authors report a series of 16 cases of familial exudative vitreoretinopathy (FEVR) in Northern Ireland (NI) to characterise the genetic patterns and identify other common characteristics relevant for current and future practice. This was a retrospective study including 12...

Amyotrophic lateral sclerosis (ALS): what happens to eye movements?

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper motor neurons of the corticospinal tract and lower motor neurons in brainstem nuclei and the anterior horn of the spinal cord. Limited literature is available on abnormal ocular movements in...

Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity

This is a retrospective review of all consecutive patients with primary (n=4) or secondary non-iatrogenic (n=16) aqueous seeding (AS) treated by intracameral chemotherapy (ICC) in Lausanne between 2011 and 2020 with a minimum follow-up of one year. Aqueous seeding control...

Is virtual reality perimetry as reliable as static perimetry in detecting neurological visual field loss?

This study compares agreement between virtual reality perimetry (VRP) and static automated perimetry (SAP) in a variety of neuro-ophthalmological conditions. For this work the Order of Magnitude (OM) VR-based visual field assessment system was used which has been developed by...

Features and associations of CVI in Australian children

The authors report the findings of an audit of data from the Australian Childhood Vision Impairment Register (ACVIR) of 132 Australian children with a primary diagnosis of cerebral visual impairment (CVI). All children were living in Australia, 49% female, 51%...

ILM peeling techniques in myopic traction maculopathy

Myopic traction maculopathy (MTM) is a sight-threatening complication of high myopia including macular retinoschisis (MRS) or foveoschisis, foveal detachment (FD) and myopic macular hole (MMH). Standard surgical treatment is vitrectomy with internal limiting membrane (ILM) peeling, but full-thickness macular hole...

Visual characteristics of spina bifida myelomeningocele

Ireland has a relatively high rate of spina bifida (SB), with a neural tube defect rate of 1.05 per 1000 births of which 47% are SB. This study was an audit of SB myelomeningocele (SBM) cases over an 8-year period,...

Genetic profiling for personalised healthcare solutions in AMD – an update

Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...