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MicroRNA inhibits corneal neovascularisation
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
Effects of topical anaesthetic on intraocular pressure
This prospective interventional study assessed the effects of repeated intraocular pressure (IOP) using Goldmann applanation tonometry and applanation resonance tonometry in six volunteers. Previous literature supports IOP reduction using repeated applanation tonometry. Repeated IOP measures were taken alternately on 12...
Effects of blood donation on the physiology of the eye
Hypovolaemia is a state of decreased blood volume, the reduction of which reduces tissue perfusion which may in turn lead to cellular hypoxia and end-organ damage. In blood donation, 500ml of blood is collected in ten minutes. This equates to...
Ranibizumab safety in pregnancy
Vascular endothelial growth factor (VEGF) plays a pivotal role during pregnancy, and systemic anti-VEGF administration during this period should thus be avoided. VEGF is expressed in multiple embryonic and foetal tissues during development, with the highest levels found in the...Ciclosporin and dry eye
Dry eye has an estimated prevalence of between 5 and 50% worldwide and has physical, psychological and socioeconomic consequences for the human population [1]. Loss of tear film homeostasis with associated ocular surface inflammation causes symptoms ranging from ‘tired’ eyes...Ophthalmic learning through the lens of cognitivism and constructivism
Learning in ophthalmology is multi-faceted, from understanding the fundamentals of eye anatomy and physiology to higher order skills such as performing cataract and vitreoretinal surgery. Having a strong foundation in the basics is a necessity for higher order knowledge synthesis,...
Surgery for third nerve palsy
The authors aimed to evaluate the results of a modified surgical method in patients with chronic total third nerve palsy: superior and inferior halves of the split lateral rectus muscle were passed under the superior and inferior rectus muscles and...
Three muscle surgery results for ET
There is limited information in the literature on the outcomes of three muscle surgery. The authors aimed to evaluate the medium term motor outcomes of three horizontal muscle surgery in 18 patients with large angle infantile esotropia of at least...
Extraocular muscle BT after ocular pathology
Management is described for 13 patients who received inferior rectus botulinum toxin (BT) injection for vertical strabismus due to orbital pathology. Patients were aged 19-86 years, eight were female and seven were right eye injections. Orbital pathology included six with...
Simultaneous surgery for ptosis and strabismus
The authors present the surgical management of congenital ptosis and coexistent strabismus at one centre for a follow-up period of >2 years. This was a retrospective review of 10 patients (17 eyes); nine males. Intermittent exotropia was present in three...
Long-term surgical success for basic exotropia
The purpose of this study was to report long-term outcomes after unilateral recess / resect surgery for basic intermittent exotropia with minimal follow-up of 10 years. This was a retrospective review of 445 patients with surgery for basic intermittent exotropia:...
