This is a retrospective study of 59 eyes with neovascuar age-related macular degeneration (nAMD) with at least 6-month remission, to determine the effect of continuing anti-VEGF injections on the progression of macular atrophy (MA) during remission of nAMD. Group 1 (30 eyes) had no further anti-VEGF injection after remission, and group 2 (29 eyes) injections were continued despite inactivity for maintenance purposes. The rate of MA progression during the remission period was measured in both groups. In group 1, the mean injections were 16.97 over 39.2 months, followed by 21 months of drug holiday. In group 2, the mean injections were 27.1 over 62.16 months, followed by a mean of 11.59 injections over 19.32 months for maintenance. The MA in the maintenance group progressed faster than the holiday group during remission (p=0.03). The authors concluded that maintenance injections for nAMD significantly increase progression of MA.
Anti-VEGF injections and macular atrophy progression in patients with nAMD in remission
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