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My Top Five: Promising gene therapies for ocular conditions

Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...

My Top Five: Promising gene therapies for ocular conditions

Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...

Adjuvant oral voriconazole or oral ketoconazole for fungal keratitis

This randomised double-blinded trial examined clinical outcomes of 50 patients with severe fungal keratitis treated with either adjuvant oral voriconazole or oral ketoconazole. Inclusion criteria were culture or smear proven fungal ulcers >5mm in maximum diameter, involving >4mm of the...

Errors in refractive surgery

A retrospective case series looking at sources of errors in patients undergoing laser refractive surgery. Twenty-two cases of error were identified in 18 patients; 15 were unilateral, three bilateral and two errors occurred in the same eye (on attempting correction...

Eye News - Covid-19: Useful resources

This list will be updated as new sources of information emerge – let us know if there’s any resources we should be listing here by emailing diana@pinpoint-scotland.com

Educational concerns and anxiety levels amongst ophthalmology trainees during the COVID-19 pandemic

How concerned are ophthalmology trainees about the present impact and the future consequences of suspended ophthalmic training programmes? Researchers in the West of Scotland investigate. Anxiety, stress and the longer-term stress reaction of burnout often go unrecognised, yet are known...

The refractive index in the eye lens – implications for clinical practice and optical design

The eye may appear to be a comparatively simple organ and yet its optical system is complex and continues to be a source of investigation and research. The major optical elements are considered to be the cornea and the lens...

Large language models in ophthalmology

Traditional artificial intelligence (AI) models typically require large amounts of labelled data for training. For example, to develop a model capable of detecting macular pathologies on optical coherence tomography scans, thousands of scans would need to be manually labelled by...

The Story of Looking: Mark Cousins

Lake, Sweden, as featured in The Story Of Looking. In an interview with Director Mark Cousins about his relationship with sight and storytelling, Peter Cackett discusses Cousins’ recent film, The Story of Looking, and how its production informed, and was...

Improving eye care for children with learning difficulties: a view from SeeAbility

Marek P Karas from sightloss charity SeeAbility examines why children with a learning disability do not access the eye care they need and asks how the system needs to change. Children with a learning disability are 28 times more likely...

The Lancet Global Health Commission on Global Eye Health: vision beyond 2020

Introduction The Lancet Global Health Commission on Global Eye Health was published in 2021 [1]. Drawing on expertise from within and outside the eye health sector, the Commission set out to: inform governments and other stakeholders about the path forward...

Management of a giant pigment epithelium detachment with transition from half- to full-dose aflibercept

This case report describes the management of a giant pigment epithelial detachment (PED) in neovascular age-related macular degeneration (nAMD) using half-dose aflibercept. An 80-year-old woman presented with a huge PED (maximum height 1338µm) and multiple risk factors for retinal pigment...