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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...
Histopathological changes in rabbit retinitis pigmentosa
The authors report the histopathological changes of retinal ganglion cells (RGCs), optic disc and optic nerve in rabbit with advanced retinitis pigmentosa (RP). RP was recreated in rabbits by using bacterial artificial chromosome transgenesis, with the purpose of increasing understanding...The bionic eye – behind the headlines
Multiple visual prosthetic projects and other vision regeneration initiatives being tested in preclinical and clinical development worldwide illustrate continuing progress and opportunities in addressing profound blindness from hereditary retinal diseases and other causes (Table 1). Three implantable bionic vision systems...“Robot performs cataract surgery on patient!”
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are scientific reality and which are ‘fake news’. Headline: “Robot performs cataract surgery on patient!” Twenty-five years ago when Eye News launched, a news headline such...Progress in retinal disease management: Highlights of the Retina Day, RCOphth 2025 Annual Congress
The Retina Day meeting at the Royal College of Ophthalmologists (RCOphth) 2025 Annual Congress in Liverpool was held on 22 May 2025. This report highlights 10 selected topics of interest to subspecialists and general ophthalmologists. Decarbonising anti-VEGF clinics (or making...AI breakthrough brings geographic atrophy treatment a step closer
A team led by Dr Konstantinos Balaskas at Moorfields Eye Hospital Reading Centre has developed a fully automated, deep-learning model (algorithm) that can detect and quantify geographic atrophy using standard optical coherence tomography (OCT) scans.Macular holes: A brief review
The classification of macular holes has been modernised by OCT findings. This is a brief review and encompasses the historical literature on macular holes. A macular hole is an anatomical discontinuation of the neurosensory retina at the centre of the...A rare case of bilateral multifocal vitelliform dystrophy
Vitelliform macular dystrophies are a subset of retinal dystrophies that result in the accumulation of lipofuscin, commonly in the macula leading to the formation of characteristic vitelliform lesions [1]. Most cases have a solitary lesion in the macula, but rarely...
Using frequency doubling technology perimetry to identify Alzheimer’s disease early
Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...Like a moth to AC flare: CMV-associated hypertensive anterior uveitis
Hypertensive anterior uveitis can present a diagnostic challenge to clinicians working in emergency eye departments. While prompt initial control of intraocular pressure (IOP) and inflammation is essential, elucidating the underlying aetiology is critical for long-term visual outcomes. When there is...
The Eye: A Very Short Introduction
I am a big fan of the ‘Very Short Introductions’ series and find them a great way to gain a basic understanding of several topics, ranging from science to philosophy. The Eye: A Very Short Introduction is no exception. It...
