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The New England Journal of Medicine cover image.

Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema

1 April 2015 | | EYE - Vitreo-Retinal
Macular oedema (MO) is a leading cause of visual impairment in patients with diabetic retinopathy. Whilst laser photocoagulation therapy has been the proven treatment for decades, studies over the last five years have also established a role for anti-VEGF agents...
Seminars in Ophthalmology journal front cover image.

G-CSF intravitreal injections for NAION: a pilot study

5 April 2022 | | EYE - Neuro-ophthalmology | Anterior ischemic optic neuropathy, Granulocyte colony-stimulating factor, Intravitreal injection, Neuroprotection, Optic atrophy
In rodent models with anterior ischemic optic neuropathy (AION), granulocyte colony-stimulating factor (G-CSF) confers a neuroprotective effect on retinal ganglion cells (RGCs) via anti-apoptotic and anti-inflammatory processes. This prospective study investigated the efficacy of intravitreal injection of G-CSF for the...
Neuro-ophthalmology front cover image.

Could idebenone by the solution for treating dominant optic atrophy?

3 September 2024 | | EYE - Neuro-ophthalmology
Dominant optic atrophy (DOA) is a disease of the retinal ganglion cells, with no current treatment options. In most cases, DOA is caused by a mutation in the OPA1 gene. The aim of this study was to evaluate the effect...
Ocular immunology and inflammation journal cover image.

Impact of initial management on relapse in Vogt–Koyanagi–Harada syndrome

3 September 2024 | | EYE - Vitreo-Retinal
In this retrospective, multi-centre, observational study, the impact of the initial management of Vogt-Koyanagi-Harada syndrome (VKHS) was assessed by reviewing the records of all patients diagnosed with VKHS between January 2001 and December 2020 in two French tertiary centres, with...
Current Eye Research journal cover image.

Fenofibrate and diabetic retinopathy

3 April 2026 | | EYE - Vitreo-Retinal
Fenofibrate is an agonist of peroxisome proliferator-activated receptor-alpha (PPARα) which is used as a lipid-lowering agent. By reducing blood lipid levels, it can decrease retinal hard exudates which is beneficial in diabetic retinopathy (DR). FIELD and ACCORD studies show that...

Cancer associated retinopathy

7 December 2020 | | EYE - Vitreo-Retinal, EYE - General
Abdul Muhyemin Tarin reviews the presentation, pathophysiology and management of this paraneoplastic syndrome. Case presentation A 60-year-old hypermetropic female patient presented with several months’ history of painless blurred vision. Visual acuity (VA) was 6/24 and 6/9-1 in right and left...

Management of diabetic macular oedema in vitrectomised eyes

1 August 2016 | | EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is one of the leading causes of blindness; its prevalence is on the rise with progressive increase in numbers of people suffering from diabetes. The management of DMO has evolved significantly over the past few years....

Do patient demographics influence AMD clinic attendance during COVID-19 lockdown?

3 June 2021 | | EYE - Vitreo-Retinal
The authors assess the impact of the COVID-19 pandemic on adherence to scheduled clinic appointments among age-related macular degeneration patients in a clinic in North Wales. The COVID-19 pandemic has significantly affected the population, affecting economic and social wellbeing, whilst...

An ophthalmology elective in Kandy, Sri Lanka

27 October 2025 | | EYE - General
On my first day at The Centre for Sight, Kandy General Hospital, I observed an enucleation. The surgeons worked with quiet precision, preserving the extraocular muscles for prosthesis placement. But when the time came, it became clear that the prosthesis...

VISION 2020 LINKS: Retinoblastoma 
in Africa

1 October 2015 | | EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal, EYE - General
The VISION 2020 LINKS Programme is part of the ‘VISION 2020: The Right to Sight’ global initiative to eliminate avoidable blindness [1]. The LINKS Programme works with overseas eye departments to help identify priorities and match their priority needs with...

Refraction planning in cataract: avoid creating an unhappy patient

1 June 2017 | | EYE - Cataract, EYE - Refractive
“It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has.” William Osler The focus of this paper is the prevention of an unhappy patient following cataract...

Feb/Mar 2016 Quiz 2

1 February 2016 | | EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal, EYE - General
History A 30-year-old male presents with a phthisical left eye and undergoes enucleation. He has some lesions in his right eye that are under ophthalmic surveillance. Figure 1 is a low power of the enucleation. Figures 2, 3 and 4...