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Feb/Mar 2014 Quiz 2

History A 65-year-old lady presented with a ten year history of nonspecific visual disturbance and mild symptoms of dry eyes. Questioning revealed progressive nyctalopia. Previous medical history of note included Crohn’s disease requiring two bowel resections including small intestine. Figure...

Importing iron to the retina

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

Treatment for chronic severe bilateral blepharokeratoconjunctivitis

This study evaluated the efficacy and safety of oral azithromycin treatment combined with topical antibiotics and anti-inflammatory agents in paediatric patients with chronic severe bilateral blepharokeratoconjunctivitis (BKC). The authors recruited 29 consecutive patients (58 eyes) with mean age at diagnosis...

Refined glaucoma referral practice offers prospect of improved capacity and expanded role for primary eye care professionals

Glaucoma is the most frequent cause of irreversible blindness worldwide and the second leading cause of blindness in the UK [1,2]. The global prevalence of glaucoma in 2010 was approximately 3.5% for people aged 40-80 years, according to Jonas et...

Sexually transmitted conjunctivitis – the REALLY sticky eye

Let’s face it, patients with conjunctivitis don’t always produce the most stimulating consultations and most of the time we can manage them in auto-pilot. The prospect of delving into such a patient’s sexual history is not overly appealing, but this...

Transcriptomic analysis of ocular tissues

Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...

A patient report of pseudoxanthoma elasticum, angioid streaks and choroidal neovascularisation

Angioid streaks (AS) on their own do not cause many problems, with the majority of patients remaining asymptomatic [1]. However, once choroidal neovascularisation (CNV) occurs, the visual prognosis of the patient rapidly declines [2]. Treatment is imperative to try and...

Neovascular AMD: fresh recommendations underline standards of best practice

The management of neovascular age-related macular degeneration (nAMD) has advanced dramatically over the past seven years, with the introduction of targeted new therapies that successfully maintain or improve vision in a majority of affected individuals. It’s a fast moving field,...

Is it NAION… Now what?

Case presentation We present the case and discussion of a 46-year-old Caucasian male who complained of immediate reduced vision following complicated neck dissection including a total laryngopharyngectomy, free flap reconstruction for a T4N3 squamous cell carcinoma (SCC) of the left...

The management of retinal vein occlusions: a summary

Retinal vein occlusions (RVO) are the most common cause of visual loss from retinal vascular disease second to diabetic retinopathy. Vision is lost due to ischaemia, macular oedema and / or haemorrhage which ultimately effects a patient’s quality of life...

Psychiatric Consequences of Ophthalmic Disease

In part two of this series on ophthalmology and psychiatry, the authors will cover the possible psychiatric consequences of ophthalmic disease. The following conditions will be discussed: a. Black patch psychosis b. Psychological state in blindness c. Phobias in the...

Corectopia grading

The authors present a novel corectopia classification system using 28 eyes of 28 patients with or without corectopia. The grading and classification system for corectopia was as follows: (i) Direction of decentration: superior (DecS), superonasal (DecSN), nasal (DecN), inferonasal (DecIN),...