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Real-world experience and outcomes of SLT laser used as a first-line treatment in ocular hypertension patients in a United Kingdom National Health Service setting

The management of raised intraocular pressure (IOP) in the context of ocular hypertension (OHT) and primary open angle glaucoma (POAG) remains a major contributor to the workload of ophthalmology units across the UK. Treatment of these conditions has historically centred...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Three years of experience with quantiferon-TB Gold Testing in patients with uveitis

Quantiferon-TB Gold is a new alternative to the tuberculin skin test that utilises synthetic peptides representing M. tuberculosis antigens ESAT-6, CFP-10, TB7.7 and upon incubation with whole blood IFN-γ is released from pre-sensitised T cells and can be measured by...

Learning from litigation: ocular drug toxicity

Being the subject of litigation is stressful and upsetting. Having to look back over your previous decisions and justify the care you delivered in good faith can be difficult. Sadly, we all live with the sword of Damocles above us...

Impact of Eye Health Surveys and Partnerships in The Gambia

This article brings together the three national eye health surveys that have been undertaken in The Gambia between 1986 and 2019 and the impact that the results have had nationally and internationally. In it we describe the long-term capacity-strengthening for...

Incidence and risk factors of late in the bag intraocular lens dislocation

The aim of this study was to identify risk factors for late in the bag dislocation over a 21 year period. Worldwide the incidence varies from 0.05% to 3.0%. In this Swedish study they report an increase in incidence in...

The PMFA Journal - April/May 2019 issue available

FEATURES IN THIS ISSUE: An update on BIA-ALCL by Shadi Ghali / The importance of teamwork and leadership in the management of patients in burns centres by Emily Claire Taylor, Steven LA Jeffery / Focus: Opinions on regulation by Dalvi Humzah, Paul Charlson, Andrew Rankin / CPD certified: Hand rejuvenation with injectable fillers by Medhat Abdelmalek AND MUCH MORE...

Nicotine accelerates diabetes induced retinal changes

This study investigated the influence of nicotine in an experimentally induced diabetic rat model. They used non-invasive high-resolution spectral domain optical coherence tomography (SD-OCT) imaging to provide quantitative information on the temporal alterations of retinal structures at the micrometer resolution...

ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy

Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...

Complement Factor H and Factor H-Like protein are expressed in human RPE cells

The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...

A pulsatile pump in the TM, a new concept in trabecular outflow research

This is a research article where the authors propose a new model in conceptualising the mechanisms involved in the aqueous outflow at the trabecular meshwork (TM). The authors demonstrated evidence of a pump within the Schlemm’s canal. A pulse generated...

HOYA Vision Care’s Defocus Incorporated Multiple Segments Spectacle Lenses demonstrated significant trend of myopia control in children

Interim analysis from the Observational French Study in children presented at EPOS 2024 meeting in Paris. Data from an interim analysis of the Observational French Study, OPHTAMYOP, has demonstrated a significant trend of myopia control in children with spherical equivalent...