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Updated staging of LCHADD retinopathy
The authors present their proposal for an updated staging system for Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) deficiency retinopathy. This is a rare mitochondrial disease due to deficiency of the long chain fatty acid oxidation pathway. Forty patients who were part of...
Understanding the pachychoroid disease spectrum
This article provides a comprehensive review of the pachychoroid disease spectrum, a group of chorioretinal disorders characterised by abnormal choroidal thickening and various pathological changes in the choroid, retinal pigment epithelium, and retina. It also highlights the controversies and knowledge...Pigmented paravenous retinochoroidal atrophy
Presentation A 46-year-old Caucasian female was referred to the eye clinic by her local optician following a routine sight test. She was noted to have pigmentary retinal changes in both eyes but was asymptomatic with no visual complaints. At presentation...Therapy for limbal stem cell deficiency: cell fate after limbal stem cell transplants
“The beauty of scientific research lies in that the search for answers often yields yet more questions.” A large body of evidence points to the corneoscleral limbal location as the repository of putative epithelial stem cells [1]. Thoft proposed the...Glucose-sensing contact lenses replace the finger prick test!
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are scientific reality and which are ‘fake news’. Headline: Glucose-sensing contact lenses replace the finger prick test! The concept of contact lenses was first illustrated by...Diabetic Macular Oedema
Diabetes mellitus is a metabolic disorder that affects the metabolism of all three categories of carbohydrates, lipids and proteins. This condition is characterised by chronic hyperglycaemia [1]. This can cause end organ damage. The estimated worldwide diabetes prevalence for 2010...
New mouse model of diabetes mellitus
Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...
Assessing and treating achromatopsia
This literature review considers clinical characteristics (pendular nystagmus, poor visual acuity, lack of colour vision and marked photophobia), genetics (autosomal recessive disease, with CNGA3, CNGB3, GNAT2, PDE6C, PDE6H and ATF6 gene mutations), diagnostic options (OCT and fundus auto fluorescence), and...
The Retinal Atlas (2nd Edition)
Those readers familiar with the first edition of The Retinal Atlas will appreciate the comprehensive nature of this publication, and this latest version incorporates retinal images generated by recently developed imaging technology. As the title suggests, this hardcover version is...
Handbook of Retinal Disease: a case based approach
This book is suitable for all doctors, particularly ophthalmologists, who want to further their knowledge and understanding of retinal pathologies and keep up to date. The case-based format is effective in evoking an interactive approach to differential diagnosis. The tabulation...
Retinal Vein Occlusions: Evidence-based Management
This reference book is designed to enable an ophthalmologist to make diagnostic and treatment decisions on the basis of the available scientific evidence. This is a very comprehensive book covering all aspects of central retinal vein occlusions including basics, clinical...
