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Multiple sclerosis and the ocular manifestations

This population study retrospectively identified patients with multiple sclerosis (MS) over a 14-year period. The aim of the study was to report the frequency and severity of ocular conditions associated with MS. Cases were identified from the Rochester Epidemiology Project....

Microdroplet and splatter contamination during phacoemulsification in COVID-19 era

Half a millilitre of fluorescein was incorporated into 400ml of balanced salt solution to identify microdroplet and splatter from phacoemulsification to simulate possible COVID-19 contamination. Five porcine eyes were mounted to an ophthalmic mannequin head and two surgeons (height 189cm,...

New solutions in the prevention and treatment of Acanthamoeba keratitis

The global increase in Acanthamoeba keratitis infections has emphasised the inefficiencies of current treatment and preventative methods, here researchers from the West of Scotland detail a promising new series of compounds that may stem the tide. News headlines detailing horror...

Ectopia lentis management

This review discusses the management of non-traumatic ectopia lentis in the paediatric population focussing on the variety of surgical options for these patients. The review considers visual sequelae and conservative management, limitations for surgery with respect to historical and current...

Brimonidine day and night time IOP

The authors describe a randomised double masked study of 29 participants with ocular hypertension (OHT) who either self-administered 0.2% brimonidine or placebo three times daily for six weeks. Patients were seen during day time and night time visits and had...

Emerging therapies for geographic atrophy: complement inhibitors show potential to slow progression and preserve RPE and photoreceptor integrity

Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) characterised by progressive, irreversible loss of the retinal pigment epithelium (RPE) and photoreceptors and is estimated to account for approximately 10% of AMD-related blindness [1-4]. The Age-Related Eye...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Three years of experience with quantiferon-TB Gold Testing in patients with uveitis

Quantiferon-TB Gold is a new alternative to the tuberculin skin test that utilises synthetic peptides representing M. tuberculosis antigens ESAT-6, CFP-10, TB7.7 and upon incubation with whole blood IFN-γ is released from pre-sensitised T cells and can be measured by...

UKISCRS Open Nominations for Three New Council Members

The UKISCRS CIO, registered number 1191256, have a vacancy for three members to join the council.

Therapy for limbal stem cell deficiency: cell fate after limbal stem cell transplants

“The beauty of scientific research lies in that the search for answers often yields yet more questions.” A large body of evidence points to the corneoscleral limbal location as the repository of putative epithelial stem cells [1]. Thoft proposed the...

Modern practice options for UK ophthalmologists

When I spoke on setting up private practice at the annual United Kingdom & Ireland Society of Cataract & Refractive Surgeons (UKISCRS) meeting in November ’23 there was a lot of interest in different types of practice models. If we...

Outcome of patients undergoing immediate sequential bilateral vitreoretinal surgery

This was a multicentre retrospective review of a case series from patients undergoing immediate sequential bilateral vitreoretinal surgery (ISBVS). A proforma was circulated to ophthalmic surgeons across the UK for cases of this rarely performed approach to collate indications, operative...