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RaScaL Study

1 June 2015 | | EYE - Vitreo-Retinal
The RaScaL study was a six month, single-centre, controlled, prospective phase I/II study in which subjects with diabetic macular oedema (DME) and associated peripheral nonperfusion on ultrawide-field fluorescein angiography (UWFA) were randomised to: (1) study arm: ranibizumab (0.5 mg) injection...

Progressive myelination of the retinal nerve fibre layer: Acquired or incidental?

4 August 2025 | | EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Paediatrics
*Co-first authors.Myelinated retinal nerve fibres are retinal nerve fibres encased by a myelin sheath, located anterior to the lamina cribrosa [1]. First described by Virchow in 1856, a myelinated retinal nerve fibre layer (RNFL) appears as a whitish, feathery patch...

An update on inherited retinal disorders (part 1) – overview and assessment of inherited retinal disease

1 October 2016 | | EYE - Vitreo-Retinal
Part 2 of this topic can be found here Inherited Retinal Disease (IRD) is the leading cause of blindness certification in the working age population (age 16-64 years) in England and Wales and the second most common in childhood [1]....

The future of binocular viewing systems?

1 December 2022 | | EYE - General
I recently had the pleasure to visit Vision Engineering’s headquarters and manufacturing facility in Woking, UK. Vision Engineering have built an international reputation for engineering microscopes that provide 3D visualisation without the use of traditional optical eyepieces. Although the company...

The ABC tragedies: Part one

2 October 2025 | | EYE - General
“In the midst of tragedy, we start the comedy” – Agatha Christie, The ABC Murders. Throughout a career in medicine, we are often faced with tragedy. One of the coping mechanisms is to use humour to navigate the mini everyday...

Headaches in ophthalmology (part 2)

1 December 2018 | | EYE - Neuro-ophthalmology, EYE - General
Ophthalmologists see a large number of patients with headaches or facial pain in the ophthalmic outpatient clinics or in emergency clinics. Over two articles, I will discuss several causes of headaches, ocular manifestations and proposed management and referral options. It...

Moorfields Eye Hospital, UCL Institute of Ophthalmology and Topcon Healthcare, Inc. launch Cascader Limited to advance AI-driven eyecare and Oculomics

9 May 2025 | AI, Artificial intelligence, oculomics, news, Moorfields, Cascader, imaging, industry news
Moorfields Eye Hospital NHS Foundation Trust, the UCL Institute of Ophthalmology (IoO), and Topcon Healthcare today announced the launch of Cascader Limited, a new medical technology company that aims to transform the detection and management of eye disease through artificial...

Landmark dataset to accelerate research on anterior segment eye disease

1 July 2026 | research, technology, diagnostics
Diseases affecting the anterior segment, the front part of the eye, are among the leading causes of visual impairment and blindness globally, yet few large-scale datasets have been available for these conditions. In response, clinical researchers at Moorfields Eye Hospital...

How to diagnose and treat Acanthamoeba keratitis

1 February 2019 | | EYE - Cornea, EYE - General
Corneal ulceration caused by Acanthamoeba is on the rise, and recent publications indicate an outbreak in the UK over the last few years [1]. Since Acanthamoeba keratitis often presents with atypical features, diagnosis from slit-lamp examination alone can often be...

Blind: Chris McCausland

4 February 2025 | | EYE - Vitreo-Retinal
In the busy, stressful lives that many of us lead, a good way to unwind in the evenings is to watch one of the celebrity panel TV shows such as Would I Lie To You? or Have I Got News...

East Bound and Down: Patrick Staropoli

2 August 2024 | | EYE - General
One of my heroes growing up in the 70s was the iconic Formula 1 racing driver, James Hunt. At the time, if you had asked me and my primary school friends what we would most like to do for a...

East Bound and Down: Patrick Staropoli

2 August 2024 | | EYE - General
One of my heroes growing up in the 70s was the iconic Formula 1 racing driver, James Hunt. At the time, if you had asked me and my primary school friends what we would most like to do for a...