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Intravitreal Ziv-Aflibercept: safety analysis
Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...
OCT biomarkers in asymmetric anti-VEGF response in bilateral diabetic macular oedema
This study aimed to identify optical coherence tomography (OCT) biomarkers for predicting response to anti-VEGF treatment in diabetic macular oedema (DMO). Bilateral DMO patients with asymmetric response to a loading dose of anti-VEGF (ranibizumab / aflibercept) treatment were retrospectively studied....
Internal limiting membrane (ILM) peeling on blood flow in diabetic macula
This is a retrospective review of notes for diabetic patients with epiretinal membrane (ERM) who underwent surgery by the same surgeon. Nineteen had ERM peeling only, while the remaining 18 had both ERM and internal limiting membrane (ILM) peeling. The...NEOS (North Of England Ophthalmological Society) Spring Meeting 2024
by Matthew Hartley, Trainee, Northern Deanery, UK. In NEOS’ 110th year, the spring meeting was held in Doncaster and centred around ocular oncology and vitreoretinal surgery. The meeting hosts, Umi Harley and Steve Winder from Royal Hallamshire Hospital, arranged a...Retina Subspecialty Day highlights from the RCOphth 2026 Annual Congress
Implementation of biosimilars in NHS retinal services A NHS England (NHSE) perspective Luke Nicholson (Moorfields Eye Hospital) explained that the NHSE perspective overall is structured on best value medicine for the patient and system, accounting for a finite budget and...Quiz Aug/Sep 2025
History A 78-year-old female presented with bilateral, painless, progressive blurring of vision over five years, photophobia and increasing glare. Her past medical history included a known diagnosis of monoclonal gammopathy of undetermined significance (MGUS). On examination, vision in the left...
Essentials of OCT in Ocular Disease
Sir Isaac Newton was the first to establish the technique of low coherence white light interferometry. Following on from this, the principle of laser interferometry as an imaging modality for retina was applied by David Huang and his associates in...Intravitreal injections delivered by ophthalmic clinical nurse specialists
Intravitreal injections of the anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab, for the treatment of wet age-related macular degeneration (AMD) was approved by National Institute for Health & Care Excellence (NICE) in 2008 [1]. The Manchester Royal Eye Hospital (MREH),...
Efficacy of intravitreal dexamethasone implant in patients with persistent macular oedema
Chronic cystoid macular oedema (CME) can develop secondary to various pathologies such as diabetic maculopathy, retinal vein occlusion and uveitis. It can cause significant visual impairment and macular damage. The therapeutic effect of corticosteroids in CME is through one or...
Effect of syringe-filling technique and risk for endophthalmitis after intravitreal injection of anti-VEGF agents
In this retrospective study the authors compare the risk for post-injection endophthalmitis between different anti-vascular endothelial growth factor (VEGF) agents and syringe preparation technique. This multicentre study included 197,402 injections. The drugs included in this study were three Anti-VEGF agents...
