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Treatment of vertical diplopia in the reading position

This paper describes the use of slab-off prisms for the treatment of vertical diplopia in the reading position. The following data were collected: main symptom complaint, visual acuity, refractive error, binocular vision including sensory fusion and stereoacuity, alternating cover test...

Reattachment rate with pneumatic retinopexy vs pars plana vitrectomy for single break rhegmatogenous retinal detachment

This is a post-hoc analysis of two clinical trials, including patients who underwent pneumatic retinopexy (PnR) vs pars plana vitrectomy (PPV) and had met the management of primary rhegmatogenous retinal detachment outcomes randomised trial (PIVOT) criteria with a single break...

RCT of surgery to correct asymmetrical DVD

This study compared the efficacy of two procedures: (1) bilateral symmetrical anteriorisation of the inferior oblique (AIO) and (2) combined resection and AIO, in cases of asymmetrical dissociated vertical deviation (DVD). This was a prospective randomised controlled trial including 54...

RCT to detect palpebral fissure changes after horizontal strabismus surgery

The aim of this prospective randomised controlled trial was to compare changes of vertical palpebral fissure h8 after bilateral lateral rectus (BLR) recession vs unilateral lateral rectus recession/medial rectus muscle scleral plication (RRP) for treatment of intermittent exotropia (IXT). Forty...

Seeing mitochondrial disease

This review highlights mitochondrial diseases as the most common inherited neurometabolic disorders, often affecting multiple high-energy organs, with eye involvement frequently representing the earliest or predominant feature. Diagnosis is challenging due to significant genetic and clinical heterogeneity, including variable expressivity,...

Two-year outcomes of repeated red-light therapy in pre-myopic children: sustained efficacy and rebound effects

This was the extended second year phase of the prospective , parallel-group, randomised, clinical trial, to evaluate the long-term prevention effectiveness and rebound effect of repeated red light therapy (RRLT) in children with pre-myopia over 2 years. A total of...

Pituitary tumours: why are they so often missed?

Part 3: Clinical features, assessment and management (see also Part 2, and Part 1) As previously mentioned in this treatise [1] pituitary tumours are common, occur in all age groups and can present with anything from minimal visual symptoms to...

Prognostic AI for diabetic retinopathy: Towards the first prospective trial in the UK

Artificial intelligence (AI) is frequently described as having the capacity to dramatically change and improve healthcare. One extensively studied application of AI in ophthalmology involves the diagnosis of diabetic retinopathy (DR) or diabetic maculopathy (DM) using retinal imaging. An emerging...

Evolving towards an interventional glaucoma mindset

Traditionally, a newly diagnosed glaucoma patient would be treated first with medical therapy. As the disease progressed or the initial intervention failed to adequately control intraocular pressure (IOP), clinicians would add more drops, selective laser trabeculoplasty (SLT), repeated SLT and...

Therapy for limbal stem cell deficiency: cell fate after limbal stem cell transplants

“The beauty of scientific research lies in that the search for answers often yields yet more questions.” A large body of evidence points to the corneoscleral limbal location as the repository of putative epithelial stem cells [1]. Thoft proposed the...

Typical and atypical optic neuritis – diagnosis and initial management

Optic neuritis is a relatively common presentation to ophthalmologists in the acute setting. The vast majority are cases of ‘typical’ optic neuritis (ON) but a smaller group of conditions, so-called, ‘atypical’ optic neuritides require a different work-up and management strategy....

The lived experience of benign essential blepharospasm

Benign essential blepharospasm (BEB) is a rare neurological condition which causes involuntary sustained or intermittent muscular contraction of both eyelids and upper facial muscles which cause closure of eyelids, abnormal facial expressions and distress [1]. The term dystonia is an...