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Analysis of risk factors for intraocular pressure rise following insertion of fluocinolone acetonide injection in uveitic patients
For this study, the authors analysed the pooled data from three phase2b / 3 multi-centre randomised controlled trials carried out over three years. Included patients had undergone at least one of the following treatments: 1) systemic therapy (corticosteroid / immunosuppressant...
Intensive diabetes therapy and ocular surgery in type 1 diabetes
The Diabetes Control and Complications Trial (DCCT) ran between 1983 and 1993 and showed that intensive glycaemic control was beneficial in reducing diabetic retinopathy in type 1 patients. There was a 76% reduction in onset of retinopathy and a 52%...
Long-term effect of gene therapy on Leber’s congenital amaurosis
After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...
Inner nuclear layer of the retina showing increase in thickness in diabetic macular oedema
Diabetic retinopathy is one of the leading causes of blindness in the developed world. With optical coherence tomography (OCT), it has become possible to image the retina in vivo and to measure retinal oedema by measuring retinal thickness (RT) with...
Mid-term evaluation of the new Glaukos iStent
This is a prospective non-randomised interventional study to assess the efficacy and safety of the Glaukos GTS-400 iStent combined with cataract surgery. The patients enrolled in the study had cataract and primary open angle glaucoma, pseudoexfoliation glaucoma or ocular hypertension....
Secondary intraocular lens implantation in children
This is a retrospective study of the medical records of children under the age of 16 who underwent secondary lens implantation for aphakic corrections after previous congenital cataract surgery over a period between January 2000 and December 2010. The study...
Mitomycin C versus 5-FU as an adjunctive treatment for trabeculectomy
Antifibrotic agents are used during trabeculectomy (TRAB) to improve long-term surgical success by reducing fibrosis of subconjunctival and episcleral tissue. The purpose of this meta-analysis was to directly compare the efficacy and safety of the two most frequently used antifibrotic...
Combined anti-VEGF and PDT for wet AMD
The authors report on a retrospective case series of combined anti-VEGF and photodynamic therapy (PDT) in the treatment of wet age-related macular degeneration (AMD) refractory to anti-VEGF monotherapy alone. The criteria for treatment failure of anti-VEGF monotherapy were persistent subretinal...
Cataract surgery in patients with retinitis pigmentosa
Retinitis pigmentosa (RP) is the commonest inherited cause of retinal degeneration. Posterior subcapsular cataract (PSC) develops in 41% to 90% of these patients by age 40 years. In this retrospective study, the authors have evaluated surgical outcomes in patients with...
Ocular lubrication versus bandage contact lens in recurrent erosion syndrome (RES)
Twenty-nine patients (eight traumatic, five epithelial basement membrane dystrophy, two idiopathic) were randomised using SPSS to either ocular lubricants or bandage contact lenses (BCLs). Only patients previously treated with ocular lubricants were included. Patients with previous surgery, laser treatment, dry...
Association between serum triglycerides and pan retinal photocoagulation in type 1 diabetes
This retrospective cohort study aimed to examine whether dyslipidaemia is a risk factor for progressing to proliferative diabetic retinopathy (PDR) and consequently requiring pan retinal photocoagulation (PRP) treatment in type 1 diabetics. In previous studies including the ETDRS study an...
