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Cytotoxic effect of voriconazole on human corneal epithelial cells

Voriconazole is a second-generation synthetic derivative of fluconazole with broadened antifungal spectrum. It is becoming the drug of choice for fungal keratitis. Voriconazole eye drops are not available commercially, thus have to be prepared by diluting the intravenous formulation containing...

The long-term effects of AREDS on AMD progression

The Age-Related Eye Disease Study (AREDS) was an 11-centre, double-masked, clinical trial that in 2001 found a high-dose of antioxidant vitamins plus zinc was effective in protecting against progression of age-related macular degeneration (AMD) in patients with moderate to high...

Brolucizumab in age-related macular degeneration, HAWK Study

The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...

The compendium to clinical evidence in DMO treatment

This review article summarises the current evidence base in the treatment options for diabetic macular oedema (DMO). The authors have included many real-world data studies that provided valuable insights into the optimal management of DMO. The authors argue that these...

The College of Optometrists launches its manifesto for eyecare in Scotland: building on success

As Scotland marks 20 years since it became the only UK nation to introduce free NHS-funded eye examinations for people of all ages in 2006, The College of Optometrists is calling on the next Scottish Government to continue leading the...

ANTS Imaging Competition 2024

Do you have an interest in ophthalmic imaging? Fancy capturing the anterior segment using a slit-lamp? Check out the new ANTS Imaging Competition.

SOS (Simplified Ophthalmic Statistics) Part 3: Which statistical test should I use (if any)?

P<0.05 is a statement that brings joy to many researchers. Arguably this is because inclusion of such a statement may increase the chance of acceptance for publication. Whilst statisticians and non-statisticians are united in trying to change this culture, cultural...

COMPlog – Electronic visual lane software

COMPlog is software designed to replace physical Snellen and LogMAR charts. We have been using COMPlog since 2017 in the unit where I work. Some readers may find our experience, and reasons for choosing this product, interesting. This article is...

Keratoconus cone variants

This retrospective study examined correlation between three keratoconic parameters to further understand anatomy of keratoconic cones. Kmax and pachymetry of the thinnest point were obtained from the Pentacam scans. Decentration was calculated as distance from the corneal vertex to the...

Fusion vergence measures

The purpose of this study was to compare fusional vergence measurements between orthophoria, esophoria and exophoria and determine the strength of correlation between fusional vergence and angle of deviation. This was a cross-section study of 530 children aged six to...

ILM peeling in primary rhegmatogenous retinal detachment

This author retrospectively analysed the correlation between internal limiting membrane (ILM) peeling and the occurrence of a postoperative epiretinal membrane (ERM) in patients who underwent vitrectomy for rhegmatogenous retinal detachment (RD). There were 135 medical records investigated. Seventy patients underwent...

Optic disc haemorrhages as a risk factor for poor outcomes in IIH

This is a report of a review of optic disc photographs, of the type and frequency of the optic disc haemorrhages (ODH), papilloedema grades and other fundoscopic abnormalities at baseline. In the study eyes of 133 patients enrolled in the...