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Maintenance therapy for CMV endotheliitis

Cytomegalovirus (CMV) has been associated with corneal endotheliitis, leading to endothelial cell loss and corneal decompensation. CMV corneal endotheliitis recurrence can affect between 5-60% of eyes after cessation of anti-CMV therapy. Each recurrence of endotheliitis has a detrimental effect on...

γδ T cell depletion does not affect fungal keratitis

Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...

Corneal stroma modelling under hypoxic conditions

The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...

Erythropoietin in healing corneal epithelial defects in rabbits

Corneal epithelial defects heal slowly in patients with diabetes, limbal stem cell deficiency and severe chemical burns. Erythropoietin is a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors as well as nonhematopoietic cells. In...

Factors influencing the outcome of GT and TBT in PCG

This is a retrospective study between 2013 to 2016 of 452 eyes of patients </=12 years with primary congenital glaucoma (PCG), who underwent either goniotomy (GT) (median age: six months, 120 eyes) or trabeculotomy (TBT) (median age: 5.2 months, 332...

IOL power calculation accuracy in childhood cataract surgery

Refractive outcomes in eyes after vitrectomy vary as the timing of cataract surgery may influence the outcome when done as staged surgery after vitreoretinal (VR) surgery or at the same time as VR surgery. The authors aimed to determine the...

A golden garden featuring famous voices among the medals at RHS Sandringham

Leading sight loss charity RNIB (Royal National Institute of Blind People) has landed three medals at a prestigious Norfolk flower show with a garden championing the power of storytelling. The imaginative design of the RNIB Talking Books Garden caught the...

Corneal transplantation in the United Kingdom: are we blind to the challenges that still exist after the Organ Donation Bill?

Corneal transplantation (CT) is a significant treatment option for a huge number of patients in the United Kingdom (UK) [1]. For an individual, CT results in a substantial improvement in quality of life. Penetrating keratoplasty with full thickness grafting has...

The meaning of life

Supercomputer: “The answer to the great question of Life, the Universe and Everything is…”Programmer: “Yes…?”Supercomputer: “42. It was a tough assignment”.Programmer: “42? Is that all you have got to show for seven and a half million years work?” In this...

From paper to pocket: Standardising eyecare with the Malawi Eye Care App

Malawi’s population is mostly rural; the government and Christian Health Association of Malawi (CHAM) together deliver about 80% of healthcare services through local district and community health facilities [1]. However, ophthalmology specialist services are only concentrated in the central hospitals....

The role of virtual Rb-NET Multidisciplinary Team meetings in the management of children with retinoblastoma in low- and middle-income countries

A selection of participants in an MDT meeting with Uganda. In 2017 the LINKS Programme developed a new network of LINKS to support and coordinate action against retinoblastoma (Rb) in response to requests from low- and middle-income countries (LMICs), called...

Return to Lviv

The ‘Return to Lviv’ trip saw Wesley McLoughlin and Doireann Hughes journey for 10 days over more than 4000 miles, via land, air and sea to deliver ophthalmic aid to Ukraine.