You searched for "regenerative"
Corneal crosslinking in pellucid marginal degeneration
Fourteen studies were included in this first review examining the use of corneal-crosslinking (CXL) to treat pellucid marginal degeneration (PMD). PMD is a bilateral, non-inflammatory corneal thinning disorder characterised by inferior peripheral corneal thinning 1-3mm from the limbus in the...
Anatomical and functional outcomes following switching from aflibercept to ranibizumab in NARMD
This is a six-month, prospective, single-arm study in the UK and Germany. A total of 100 patients were enrolled (one in the primary failure group, 99 in the suboptimal treatment response group), treated three-monthly intravitreal ranibizumab injections (0.5mg), and then...
The effects of anti-VEGF therapy for NvAMD on retinal vasculature
This retrospective consecutive case series examined 54 eyes of 54 treatment-naïve neovascular age-related macular degeneration (N-AMD) patients. Thirty-three eyes received intravitreal aflibercept injections, and 21 eyes received intravitreal ranibizumab injections with unaffected fellow eyes (54 eyes) as controls. All image...
Progression of macular atrophy on long-term anti-VEGF therapy for AMD
This retrospective study evaluated the progression of macular atrophy in 53 eyes of 53 patients receiving AntiVEGF Therapy for age-related macular degeneration (nAMD), for at least six years. None of the patients had any macular atrophy (MA) at presentation. MA...
OCT prognostic factors in AMD patients with peripapillary choroidal neovascularisation
In this retrospective study the authors aimed to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularisation (PPCNV). Data...
Submacular haemorrhage associated with nAMD: A meta-analysis and meta-regression on use of tPA and anti-VEGFs
The aim of this study was to evaluate the efficacy of a combination of tPA and anti-VEGF in the treatment of submacular haemorrhage (SMH) associated with neovascular age-related macular degeneration (nAMD). A systematic review meta-analysis following PRISMA guidelines, focusing on...Through the eyes of artists, part two: The effects of retinal degeneration on Degas and O’Keeffe
Last issue we discussed Monet and Cassatt’s experience of painting through cataract. We now move to two stories of resilience in the face of macular degeneration, Edgar Degas and Georgia O’Keeffe. Edgar Degas. (c1873) ‘The Dance Class’, oil on canvas....
Early biomarker for paraneoplastic retinopathy
This informative case series evaluates 4 eyes of 2 patients presenting with rapidly progressive vision loss secondary to cancer-associated retinopathy. The authors identified a distinct spectral-domain optical coherence tomography structural feature termed the angular sign of Henle fibre layer hyperreflectivity...Sickle cell eye disease: an overview of vitreoretinal complications and their surgical management
Sickle cell disease is the most common genetic disorder worldwide and is associated with lifelong anaemia, intermittent pain and multi-organ morbidity. Ocular involvement can be associated with significant visual impairment due to the complications of proliferative sickle retinopathy (PSR). Occasionally...
Does bariatric surgery prevent progression of diabetic retinopathy?
The authors report a retrospective observational study of T2DM patients who underwent bariatric surgery between 2009 and 2015. Preoperative and postoperative weight, HbA1c, and annual diabetic retinopathy (DR) screening results were obtained from medical records. Patients with preoperative retinal screening...
Treatment for post stroke visual impairment – clinical practice versus literature evidence
The aim of this paper is to compare the treatments reported in a large scale stroke study (Vision in stroke (VIS) Study) against the treatments identified in a full systematic literature review. The purpose was to identify which treatment /...
