OCT prognostic factors in AMD patients with peripapillary choroidal neovascularisation
Reviewed by Sofia Rokerya

In this retrospective study the authors aimed to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularisation (PPCNV). Data was identified by electronic medical records and patients with PPCNV temporal to the optic disc secondary to AMD were included in the study. Thirty eyes of 30 patients aged 84.3 ±6.9 years 63.3% of which were females were included. The CNV was located in the superior half in 73.3% of cases. The baseline BCVA was 0.46 ±0.62 logMAR (Snellen 20/57), average choroidal thickness was 193.2 ±22μm, and mean number of IVB injections was 7.2 ±1.9. After 12 months of treatment and follow-up, there was no significant change in BCVA (0.46 ±0.62 versus 0.56 ±0.78, p=0.28) (Snellen 20/57 vs. 20/72). (p=0.28). It was noted that eyes with greater central retinal thickness (r=-0.36, p=0.05), greater subretinal hyperreflective material (SHRM) area (r=-0.37, p=0.05), and greater sub-retinal fluid (SRF) area (r=-0.73, p<0.001) had a significantly smaller improvement in BCVA. Eyes with pigment epithelium detachment (PED) (0.68 ±0.90 versus 0.21 ±0.12, p=0.03) had a significantly worse BCVA. The data suggested that AMD-related PPCNV with greater foveal thickness, PED size, SHRM and SRF areas have worse final BCVA prognosis. Limitations of the study include its retrospective nature and relatively small study population. In addition, it is noteworthy that the location of SRF, IRF and PED which may also have influenced the visual acuity were not assessed in this study.

Optical coherence tomography prognostic factors in age-related macular degeneration patients with peripapillary choroidal neovascularisation.
Rabina G, Ayalon A, Mimounic M, et al.
OPHTHALMOLOGICA
2022;245(4):342-9.