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Eye Surgery in Hot Climates (Fourth Edition)
The Fourth Edition of Eye Surgery in Hot Climates by William Dean and John Sandford-Smith has made a debut at a time when there is a surge of interest in global ophthalmology amongst novices and experts alike. Both authors have...
Retreatment of myopic LASIK with femtosecond and custom ablation
The purpose of this study was to identify the risk factors for retreatment post laser in situ keratomileusis (LASIK). A retrospective chart review was carried out for a four-year period and all patients who had undergone LASIK at the Boston...
Finasteride and central serous chorioretinopathy
The pathophysiology of central serous chorioretinopathy (CSC) is complex and has not been fully elucidated. Suggested theories include hyperpermeability and increased hydrostatic pressure in the choroidal vasculature, which creates RPE detachments overwhelming the RPE barrier function, leading to accumulation of...
Risk factors for intraoperative floppy iris syndrome
Intraoperative floppy iris syndrome (IFIS) is charcterised by flaccid iris stroma leading to fluttering and billowing of iris, tendency of iris to prolapse through surgical incisions and causing intraoperative pupil constriction. IFIS is characterised as complete when all three features...
Mast cells in Graves’ ophthalmopathy
Graves’ ophthalmopathy (GO) is a potentially sight-threatening ocular disease, occurring in patients with hyperthyroidism due to Graves’ disease. Also known as thyroid-associated ophthalmopathy, GO is characterised by orbital infiltration by immune cells including macrophages, T cells and plasma cells, which...
Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease
In recent years artificial tear drops addressing tear film osmolarity have come onto the market. Increased tear evaporation and reduced tear volume results in tear hyperosmolarity. This triggers an inflammatory process leading to apoptosis of goblet and epithelial cells. Trehalose,...
SLT vs. topical treatment with prostaglandin analogues in the management of PACG
Selective laser trabeculoplasty (SLT) has been shown to be useful in the management of primary open angle glaucoma (POAG), but its use in primary angle closure (PAC) / primary angle closure glaucoma (PACG) has yet to be validated. Narayanaswamy et...
Inhibiting high-risk corneal allografts
The cornea is an immune privileged site and as such corneal transplants are very successful. However, in situations where this privilege is lost the failure rises substantially. To combat rejection inhibition of the immune responses depends on steroids and other...
Automated grading of diabetic retinopathy: is it possible?
Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a leading cause of blindness worldwide. However, much of this diabetic blindness can be delayed or even prevented with timely diagnosis and proper treatment. For this reason, regular screening...
CD40L activation of human RPE cells
Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...
Optical coherence tomography in patients exposed to vigabatrin
Vigabatrin is used to treat epilepsy and can lead to increased levels of gamma-aminobutyric acid (GABA) in the brain and in the retina leading to binasal visual field defects. Although not the first line of treatment for adults it is...
