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The role of inflammation in the pathophysiology of DMO

1 February 2016 | | EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

Genetic profiling for personalised healthcare solutions in AMD – an update

1 August 2015 | | EYE - Vitreo-Retinal
Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...

Contemporary glaucoma therapy: spoilt for choice

1 April 2014 | | EYE - Glaucoma
The goal of glaucoma management is to prevent visual loss and disease progression in the patient’s lifetime through effective lowering of intraocular pressure (IOP), the primary modifiable risk factor in glaucoma. Sustained and consistent IOP reduction is key to halting...

Rare eye diseases: progress continues with authorised orphan medicines and breakthrough technologies

1 October 2018 | | EYE - General
An update on the development of orphan medicines, recent regulatory treatment approvals for rare eye conditions and advances in retinal prosthetic technologies for blinding diseases. The prevalence of a rare disease is based usually on a range of estimates and...

Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease

5 February 2020 | | EYE - Vitreo-Retinal, EYE - General
Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...

The use of toxin in paediatric strabismus

4 December 2025 | | EYE - Paediatrics
Strabismus is a common condition that affects up to 5% children and can be associated with abnormal visual development, double vision, loss of depth perception and impaired binocularity [1]. It can also cause cosmetic concerns, negatively impact psychosocial wellbeing and...

What's trending Apr/May 2018

1 April 2018 | | EYE - Pathology, EYE - Oncology, EYE - General, EYE - Cornea
A round-up of the eye related hot topics that have been trending on social media over the last few weeks. Hello again, it’s snowy outside on this March day in the UK. The news of late has been dominated by...

What's trending Feb/Mar 2020

5 February 2020 | | EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
#gbhockey #samward #sight Great Britain Hockey player Sam Ward, described as one of the “deadliest attackers in world hockey” [1], sustained a sight-threatening injury after being struck in the face by a ball during the Olympic qualifying match against Malaysia...

A paediatric case of central retinal artery occlusion following antibiotics and decompression surgery for orbital cellulitis

3 October 2022 | | EYE - Paediatrics, EYE - Strabismus, EYE - General
Orbital cellulitis is an ophthalmic emergency that warrants urgent management in the hospital setting [1]. This occurs more frequently in the paediatric population where it is often secondary to sinus infections. Delay in treatment could result in severe complications including...

Progressive myelination of the retinal nerve fibre layer: Acquired or incidental?

4 August 2025 | | EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Paediatrics
*Co-first authors.Myelinated retinal nerve fibres are retinal nerve fibres encased by a myelin sheath, located anterior to the lamina cribrosa [1]. First described by Virchow in 1856, a myelinated retinal nerve fibre layer (RNFL) appears as a whitish, feathery patch...

Orbital cellulitis - an overview of the diagnosis and management

1 February 2022 | | EYE - Orbit, EYE - Neuro-ophthalmology, EYE - Imaging, EYE - General
Periorbital (preseptal) and orbital cellulitis are infections of the subcutaneous tissues of the eye. They are differentiated by the location of the infection. Periorbital cellulitis refers to infection of the eyelid and subcutaneous tissues anterior to the orbital septum, whereas...

My top five: Emerging alternatives to manage and treat nAMD

3 April 2024 | | EYE - Vitreo-Retinal
Wet (exudative or neovascular) age-related macular degeneration (AMD) is characterised by choroidal neovascularisation, in which new blood vessels from the choroid invade through Bruch’s membrane. These blood vessels proliferate beneath or through the retinal pigment epithelium (RPE), causing patients to...