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RPTP-σ increases pro-MMP activity in a trabecular meshwork cell line following oxidative stress conditions

This study aims to outline the role of phosphatases in the aqueous drainage system by overexpressing receptor tyrosine phosphatase sigma (RPTP-σ) in a human normal trabecular meshwork cell line and describing its effect on subtypes of matrix metalloproteinases (MMP) and...

PD-1 and retinal ganglion cell death

Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...

Limbal melanocytes and the stem cell niche

The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...

The impact of conjunctivochalasis on dry eye symptoms and signs

The study aimed to draw a relationship between conjunctivochalasis and dry eye symptoms via a dry eye questionnaire (DEQ5), as well as signs such as tear osmolarity, tear break up time, corneal staining, Schirmer score, meibomian gland dropout, eye lid...

Optic nerve head perfusion response to reduced blood pressure and increased intraocular pressure

The purpose of this prospective study was to test the hypothesis that blood flow autoregulation in the optic nerve head has less reserve to maintain normal blood flow where there is a blood pressure induced decrease in ocular perfusion pressure...

International orthoptics for stroke

The purpose of this study was to consider the practice of orthoptists internationally in care provision for post stroke visual impairment through an international survey. An online survey of 30 questions was circulated via the International Orthoptic Association and completed...

A tarso-conjunctival flap for paralytic ectropion

This is a review of 110 patients with paralytic ectropion who underwent a lateral tarso-conjunctival flap procedure. The technique involves fashioning a 4-8mm wide lateral tarso-conjunctival flap in a similar way to a lateral Hughes flap. This is then sutured...

Diagnostic procedures in vitreoretinal lymphoma.

This paper presented a retrospective review of medical records of HIV negative immunocompetent patients diagnosed with vitreoretinal lymphoma between 1994 and 2012. The aim of the paper was to evaluate the type and number of diagnostic interventions required to confirm...

RPE use similar pathway to regulatory T cells to inhibit immune response

Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....

MicroRNA mediate retinoblastoma signal transduction

MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...

Diagnosis and management of orbital vascular malformations

This is an authoritative review of a controversial and difficult clinical area. The authors have experience of over 350 cases and provide a well-structured review of the classification and management of orbital vascular malformations. They emphasise the need to understand...

Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)

The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...