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Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Cataract surgery and long-term risk of glaucoma in PEX

The objective of this study was to compare the development of glaucoma and IOP over an extended time period following cataract surgery in eyes with and without pseudoexfoliation syndrome (PEX), and trying to determine the impact of cataract surgery on...

Retinal blood flow changes in glaucoma

This study examined the changes in retinal blood flow and vessel diameter after IOP reduction in high- and low-pressure glaucoma; exfoliation glaucoma (ExG) and normal-tension glaucoma (NTG). Glaucoma progression is seen at times in eyes despite IOP reduction and changes...

Automated grading of diabetic retinopathy: is it possible?

Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a leading cause of blindness worldwide. However, much of this diabetic blindness can be delayed or even prevented with timely diagnosis and proper treatment. For this reason, regular screening...

Should intravitreal steroids be used in the initial treatment of post-op endophthalmitis?

Endophthalmitis following cataract surgery is one of the most feared complications, and can have significant impact on the visual outcomes of patients. The role of steroids in the management of endopthalmitis is controversial. The aim of this paper was to...

Does Ozurdex affect perfusion status in vein occlusion?

Ozurdex (intravitreal dexamethasone implant) has been approved by National Institute of Health & Care Excellence (NICE) for treatment of patients with macular oedema associated with vein occlusion. This study looks at the change in peripheral perfusion status in patients with...

Light tolerance in infectious keratitis

The authors presented the findings of a study that aimed to identify the maximum irradiance (power received by a surface per unit area) that can be tolerated by photophobic patients with infectious keratitis (IK). They recruited 30 patients (14 women...

Uveitis‐Glaucoma‐Hyphaemia syndrome retrospective case-control study

The authors present the findings of a case-control study aiming to assess uveitis‐glaucoma‐hyphaemia (UGH) syndrome, focusing on the resolution, glaucoma development and risk factors. The authors compared three groups each containing 71 patients. Each group contained patients with UGH syndrome,...

Assessing failure of laser coagulation treatment for type 1 retinopathy of prematurity

The authors present the findings of a retrospective study to examine the cause of treatment failures in type 1 retinopathy of prematurity (ROP). They reviewed the medical charts of all infants with persistent disease post laser treatment at Uppsala University...

Oral glycerol effect on anterior chamber depth during cataract surgery

The authors present the findings of a controlled clinical trial where cataract patients having surgery for both eyes at least seven days apart were given oral glycerol preoperatively when operating on the right eye. This meant that the left eye...

Practical Handbook of OCT (Retina, Choroid, Glaucoma)

With the rapid development and expansion in the usage of optical coherence tomography (OCT) technology there is always demand for a new OCT publication on the bookshelves. The operation and acquisition skills required are more easily acquired than for the...