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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service

4 August 2021 | | EYE - Paediatrics, EYE - Vitreo-Retinal, EYE - General
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...

Ophthalmic Aid to Eastern Europe (OAEE)

4 March 2022 | | EYE - General
Peter Cackett, Tim ffytche and Dr Irina Gout reflect on historic ophthalmic aid sent to Eastern Europe. This article was written prior to the horrific events in Ukraine. An appeal for funds and equipment may be made by OAEE later...

Post-stroke visual impairment: how big is the problem, how do we identify it, what we can do about it, and why does it matter?

1 December 2022 | | EYE - General
In the UK, 100,000 new strokes occur each year, with 1.3 million stroke survivors [1]. This article will focus on post-stroke visual impairment, discussing topics of how common it is, how it can be detected, possible management options and how...

Ophthalmology in a War Zone: an interview with Dr Volodymyr Melnyk

7 December 2022 | | EYE - General, EYE - Cornea, EYE - Cataract, EYE - Glaucoma
It is now nine months since the full-scale Russian invasion of Ukraine commenced in late February 2022, with Putin announcing a “special military operation” to “denazify and demilitarise” Ukraine. The rest of the world, however, saw it for what it...

Investigating the link between corneal clarity and statin use

2 February 2024 | | EYE - Cornea
Transparency is a vital attribute of the cornea, necessary in preserving healthy vision. Maintaining this requires the collective input of the various layers of the cornea. Mostly, the layers implicated in this are the corneal stroma and endothelium [1]. Our...

Part 3: The Arclight Project: Implementation workshops

2 August 2024 | | EYE - General
In this three-part series (Click here for Part 1 and Part 2) Andrew Blaikie and his team explore the role and application of the Arclight Device in Imaging of the Eye. The Arclight Project aims to support and enhance the...

The lived experience of benign essential blepharospasm

4 December 2025 | | EYE - Oculoplastic
Benign essential blepharospasm (BEB) is a rare neurological condition which causes involuntary sustained or intermittent muscular contraction of both eyelids and upper facial muscles which cause closure of eyelids, abnormal facial expressions and distress [1]. The term dystonia is an...

Paediatric optic disc anomalies

4 December 2025 | | EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Paediatrics
Anomalies of the optic nerve are relatively rare, but account for a significant proportion of sight impairment in children and adults. The recognition of these anomalies by eye health professionals is important not only due to their potential impact on...

Understanding and confronting bacterial endophthalmitis

2 December 2019 | | EYE - Cornea, EYE - Vitreo-Retinal, EYE - General
Abdus Samad Ansari highlights the importance of early recognition of this condition using an unusual presentation. Endophthalmitis is a medical emergency with devastating consequences. Despite adequate treatment, severe cases frequently result in permanent blindness. Endophthalmitis involves inflammation of both the...

A revolution in modern genetic testing for the clinical management of ocular disease

1 August 2016 | | EYE - Cataract, EYE - Pathology, EYE - Vitreo-Retinal
Recent years have seen a huge increase in our understanding of the genetic factors underlying a wide variety of eye diseases. This has included common conditions such as glaucoma and age-related macular degeneration, as well as those conditions which have...

Typical or surprisingly uncharacteristic presentations of neuro-ophthalmic emergencies

1 April 2019 | | EYE - Neuro-ophthalmology, EYE - General
Irrespective of geographical location or patient cohort, emergency departments are high risk locations capable of inspiring extreme anxiety and dread in patients and doctors alike. The stress multiplies when a walk-in or referred case is suspected of underlying neurological pathology....

The management of antiplatelets and anticoagulation in elective ophthalmic surgery

1 April 2016 | | EYE - Orbit, EYE - Oculoplastic
Clinical scenario: A 57-year-old gentleman who is scheduled to have Mohs micrographic surgery and reconstruction for a medial canthal basel cell carcinoma (BCC) has been started on aspirin and clopidogrel following a coronary stent three weeks ago. Does the antiplatelet...