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SOS (Simplified Ophthalmic Statistics) Part 3: Which statistical test should I use (if any)?

P<0.05 is a statement that brings joy to many researchers. Arguably this is because inclusion of such a statement may increase the chance of acceptance for publication. Whilst statisticians and non-statisticians are united in trying to change this culture, cultural...

Efficacy and safety of novel PF brimonidine / timolol fixed-combination ophthalmic solution for OAG

This study is a multicentre, randomised, open-label, parallel-group clinical trial to evaluate the efficacy and safety of a newly developed preservative-free (PF) brimonidine / timolol fixed-combination (BTFC) ophthalmic solutions as compared with preservative-containing (PC) BTFC ophthalmic solution in adult patients...

Africa makes strides in tackling blinding eye diseases: highlights of annual conference

Introduction The 9th Annual Scientific Conference of the College of Ophthalmology of Eastern, Central and Southern Africa (COECSA) was held at the Bingu International Convention Centre in Lilongwe, Malawi in September 2022. The meeting was hosted by the Ophthalmological Society...

Systemic pharmacology of intravitreal anti-VEGF

This study aimed to evaluate and compare serum drug concentrations and plasma free-VEGF concentrations in patients with AMD, DME, or RVO receiving intravitreal injections of aflibercept, bevacizumab or ranibizumab. This prospective study enrolled patients from several offices of a single...

Iranian prevalence of amblyopia

This population-based study was conducted in the Mashhad County in the north east of Iran to determine the prevalence of amblyopia and its determinants and to predict the health needs of the county. This was a cross-sectional study and of...

Optimising an acute eye service in the current COVID-19 crisis

With the current global pandemic of COVID-19 we have all had to redesign and reorganise our normal working practices. Non-urgent hospital work has been postponed to allow redistribution of resources, redeployment of hospital staff and to reduce the risk of...

Normal reference values for the RETeval device

The purpose of this study was to provide normative data of full-field electroretinography (ERG) responses in the paediatric population using the RETeval device in healthy children with normal retinas. This was a prospective study of 38 eyes of 20 patients...

Collaborating across the Caribbean to tackle diabetic retinopathy

The VISION 2020 LINKS Programme has been running since 2004, with a focus on improving the quality and quantity of eye care training in low-income countries [1]. In 2014, the Diabetic Retinopathy Network (DR-NET) was established [2]. This is a...

Valuable resources for FRCOphth Part 1 exam preparation

The FRCOphth Part 1 exam is a difficult exam with an average pass rate of 46% in the last year. It is a requirement before entry into the third year of ophthalmology specialty training (OST). Passing this exam during foundation...

Comparison of SIA from femtosecond laser and manual CCIs for cataract surgery

This study group compared the differences in surgically induced astigmatism (SIA) vector, flattening effect, torque and wound architecture following both femtosecond laser and manual clear corneal incisions (CCIs). A double-armed, randomised, prospective case series was conducted. Cataract surgery was performed...

An introduction to research governance

Research is the process of acquiring new generalisable knowledge and should be fully integrated into health care work. There is a growing drive to encourage and further develop evidence-based practice in ophthalmology so that staff and patients benefit from improved...

In conversation with Dr Robert B Nussenblatt

Dr Robert B Nussenblatt is Chief of the Laboratory of Immunology at the National Eye Institute, an eminent ocular immunologist and an expert in clinical research design and conduct. Describe the success or relevance of the SUN project. The Standardization...