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Likelihood of developing multiple sclerosis after optic neuritis diagnosis

Optic neuritis (ON) is a relatively common cause of acute optic neuropathy in young patients which often presents as the first sign of multiple sclerosis (MS). There is a lack of evidence around the factors that are associated with the...

A review of neuro and retinal imaging findings in Alzheimer’s disease

The authors present a systematic review with the aim of assessing the relationship between retinal and cerebral changes in Alzheimer’s disease (AD), mild cognitive impairment and pre-clinical AD. A total of 23 articles met the inclusion criteria of the review,...

Single case report of horizontal gaze paresis due to medial pontine haemorrhage

The authors report a single case (80-year-old female) of bilateral horizontal conjugate gaze palsy due to a dorsal median pontine haemorrhage. The patient presented with skew deviation, bilateral horizontal conjugate gaze palsy, vertical gaze palsy, ipsilateral lower motor neuron facial...

Prognosis prediction using clinical findings for fourth nerve palsies

The authors present a retrospective review of a cohort of patients diagnosed with fourth cranial nerve palsy with more than six months follow-up, over a 10-year period at a single centre. Thirty-five patients were included in the study, and spilt...

Test combination which could detect prodromal Alzheimer disease

The authors prospectively recruited a convenience sample of individuals aged over 65 and either with a diagnosis of mild cognitive impairment (MCI) due to Alzheimer disease or normal cognition. Other types of dementia and severe neurological conditions were excluded. All...

Using optical coherence tomography angiography to detect MoyaMoya vasculopathy

Moyamoya (MM) disease is a chronic cerebrovascular disease that can lead to progressive stenosis of the terminal portions of the internal carotid arteries and their proximal branches. The authors carried out a cross-sectional cohort study to investigate vascular changes in...

Long-term treatment for diabetic macular oedema

The authors set out to characterise anti-VEGF treatment patterns and long-term outcomes in patients with diabetic macular oedema. A retrospective analysis of over 190 thousand patients on the Intelligent Research in Sight registry was performed. Of these, 1236 eyes have...

Parent-reported outcomes after cerebral hemispherectomy

The authors present the findings of a survey circulated by the Childhood Epilepsy Surgery Foundation to its members. Parents of children who had undergone a cerebral hemispherectomy were invited to participate. A total of 48 responses from 248 who were...

Can the angle of origin of the ophthalmic artery predict embolic trajectory?

A retrospective, comparative case-control study was used to test the hypothesis that a risk factor for retinal versus cerebral infarct is the angular origin of the ophthalmic artery from the internal carotid artery. The study compared one group (n=28) who...

Thalamic infarcts and the associated neuro-ophthalmic sequelae

The authors present a retrospective review of clinical and imaging data from a stroke database over a 10-year period. Of those identified as having a thalamic infarction (n=342), 40 were found to have neuro-ophthalmic sequelae (11.7%). The neuro-ophthalmic sequelae reported...

Relationship between intraocular pressure and optic nerve damage in optic nerve drusen

The authors present a retrospective study exploring the relationship between intraocular pressure (IOP) and optic nerve damage in patients with optic nerve drusen. The aim was to evaluate if patients with normal ocular pressure at the time of optic nerve...

Migraine attack: does retinal and peripapillary blood flow change?

This prospective clinical study compared retinal and peripapillary blood flow parameters in migraine patients during an attack with healthy controls using optical coherence tomography angiography (OCTA). OCTAs were performed on 52 eyes from 26 migraine sufferers and 48 eyes from...