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Danger Zone: Miles Hilton-Barber

“Life is either a daring adventure, or nothing at all” – Helen Keller, deafblind American author, activist, and disability rights advocate I have always had a thirst for adventure, even if it has been predominantly from the comfort of my...

The original smooth operator: Sir Robin Millar

As an early 80s kid, if you lacked sufficient pocket money, building a music collection entailed recording your favourite songs off the radio with a cassette deck and hoping the presenter didn’t interrupt at any point, with a finger hovering...

Advances in the understanding, diagnostic and treatment of keratoconus

*Joint first authors Keratoconus is a bilateral and asymmetric eye condition in which the cornea’s structure is affected and thinned, causing a cone-shaped bulge to develop. This results in progressive loss of vision and impairs the ability of the eye...

Dark circles and facial rejuvenation

A 45-year-old socialite lady comes for cosmetic consultation and wants a remedy for dark circles and facial ageing. How do you manage this patient? Issues of dark circles and facial ageing should be addressed separately. Facial ageing should be considered...

Comparison of vision screeners

The primary purpose of this study was to calibrate the various paediatric photoscreeners over a range of contact lens induced hyperopic and astigmatic anisometropia using the American Association of Paediatric Ophthalmology and Strabismus (AAPOS) criteria for anisometropic or axial astigmatism....

Do topical steroids improve visual outcome in the treatment of bacterial keratitis?

The use of topical corticosteroids as an adjunctive treatment to antibiotics in the management of bacterial keratitis remains a controversial issue. The results of the Steroids for Corneal Ulcers Trial (SCUT) – a randomised, double-masked, placebo-controlled trial that recruited patients...

Transient thickening of the macular retinal nerve fibre layer in acute optic neuritis

Acute optic neuritis (ON) causes axonal degeneration, which can be quantified from the blood by neurofilament protein (Nf) levels. Within about three months, atrophy of the retinal nerve fibre layer (RNFL) follows. However, it remains challenging to explain why there...

Microbiology, risk factors and outcomes of microbial keratitis in Sydney, Australia

The authors present a retrospective case series including all patients with microbial keratitis and ocular surface diseases (OSD), including dry eye, blepharitis, Stevens-Johnson syndrome and / or ocular cicatricial pemphigoid, over a five-year period between 2012 and 2016. A total...

Rituximab efficacy for juvenile idiopathic arthritis

This is a retrospective study about the long-term efficacy of rituximab in patients with severe juvenile idiopathic arthritis (JIA)-associated uveitis. A total of eight patients (15 eyes) were recruited in this study in a single tertiary referral centre from Italy....

The last three patients: general practice (Patient One)

Professor Jonathan Rees is an Emeritus Professor of Dermatology at the University of Edinburgh (2020). He held the Grant Chair of Dermatology in Edinburgh from 2000 to 2020, and before that the Chair of Dermatology in Newcastle from 1992 to...

RPE use similar pathway to regulatory T cells to inhibit immune response

Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....

Patient education in ophthalmology: Contact lens wearers

Contact lenses provide effective vision correction for approximately 4.5 million people in the UK [1]. However, their improper use and poor hygiene practices contribute to increased risk of contact lens-related complications. Furthermore, a study in the USA showed that 99%...