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Limitations of next generation sequencing
This is a report of a young female patient with clinically diagnosed retinitis pigmentosa who underwent genetic testing using an inherited retinal disease panel and whole exome sequencing by next generation sequencing (NGS) technology. This approach did not identify any...
Review of pathogenesis of Acanthamoeba keratitis
In this review, the author summarised the current microbiomic and immunological evidence related to the pathogenesis of Acanthamoeba keratitis (AK). AK has been described for almost 50 years, but the exact biology of the disease remains perplexing. Acanthamoeba spp. are...
Uveitis in HIV infected persons
Before the advent of highly active antiretroviral therapy (HAART), uveitis, in particular cytomegalovirus (CMV) retinitis, was the most common cause of visual loss in patients with AIDS. HAART has altered the cause of ocular disease in HIV infected individuals by...Tear Trough Filler Masterclass
Join us for a full-day course at our Harley Street clinic, where we discuss the lessons learned from unique expertise in treating thousands of patients. The course includes an in-depth understanding of the anatomy of the tear trough, patient and...Strabismus in thyroid eye disease
Pathogenesis Thyroid eye disease (TED) is an auto-immune condition, in the initial phase there is lymphocytic infiltration and oedema of the extraocular muscles with deposition of glycosaminoglycans and hyaluronic acid and adipogenesis, which can lead to an increase in the...
Systemic pharmacology of intravitreal anti-VEGF
This study aimed to evaluate and compare serum drug concentrations and plasma free-VEGF concentrations in patients with AMD, DME, or RVO receiving intravitreal injections of aflibercept, bevacizumab or ranibizumab. This prospective study enrolled patients from several offices of a single...
Scheimpflug images and graft rejection
This study aimed to assess corneal changes using 360-degree Scheimpflug images and pachymetry readings to outline screening parameters, which define graft rejection. Seventeen eyes of 16 patients developed clinically manifest allograft rejection two to 42 months after surgery – those...
Update: Non-infectious retinal vasculitis
This review article summarises the update on non-infectious retinal vasculitis (RV). It is primarily classified based on the type of retinal vessels involved and further sub-classified as occlusive or nonocclusive. Clinically it can occur as an isolated ocular entity or...
First systematic review of COVID-19 colonisation of ocular tissues and secretions
The authors present the first systematic review summarising all the data regarding SARS-CoV-2 colonisation of ocular and periocular tissues and secretions. They reviewed all publications between December 2019 to April 2020 in the Cochrane Library, Medline, World of Science and...
Subfoveal choroidal thickness and PCV
This report studies the prognostic factors for visual improvement and the need for additional treatments at one year after the initial combination therapy of intravitreal ranibizumab injection or intravitreal aflibercept injection followed by PDT in eyes with PCV. Fifty-six eyes...
