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This is a review article looking at the differential diagnosis of subretinal fluid in the macula that could be diagnosed as central serous chorioretinopathy (CSCR). The authors have categorised them into 12 groups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular tumours, haematological malignancies, paraneoplastic syndromes, genetic diseases, ocular developmental anomalies, medication-related conditions and toxicity-related diseases, rhegmatogenous retinal detachment and tractional retinal detachment, retinal vascular diseases and miscellaneous diseases. The authors have compiled comprehensive clinical characteristic features for each condition and treatment options if available. The article is a helpful tool in differentiating subretinal fluid on optical coherence imaging, particularly in challenging cases.

The differential diagnosis of central serous chorioretinopathy and other diseases associated with subretinal fluid in the macula.
van Dijk E, Boon C.
2021; Epub ahead of print.
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Zhihang Cheng

Alder Hey Children’s Hospital, Liverpool, UK.

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