The authors present the findings of a case-control study aiming to assess uveitis‐glaucoma‐hyphaemia (UGH) syndrome, focusing on the resolution, glaucoma development and risk factors. The authors compared three groups each containing 71 patients. Each group contained patients with UGH syndrome, dislocated intraocular lens (IOL) without UGH syndrome or ordinary pseudophakia. The median follow-up time of patients with UGH was 1.8 years after surgery, or after the decision to not operate. The authors defined UGH as a condition with an IOL-Iris contact causing intraocular haemorrhages or uveitis with pigment dispersion or macular oedema. In the UGH group, 60 patients received surgical treatment while the remaining 10 had non-surgical treatment. The authors also assessed the use of IOP lowering agents as a measure of IOP control after symptom resolution by analysing the following risk factors: IOP at first haemorrhage, duration between UGH syndrome and IOL surgery and whether surgery was performed or not. Use of blood thinners was also compared between the dislocated and the UGH groups. The results showed that UGH syndrome resolved in 77% of patients who had different forms of IOL surgery. Intraocular pressure (IOP) decreased and visual acuity improved in the operated cases (p=0.02 and p<0.001). No significant improvement was noted in cases treated conservatively. High IOP (≥22mmHg) at the first haemorrhage foreshadowed the need of glaucoma therapy after UGH syndrome resolution (p=0.002, area under the curve = 0.8). Fifty-one percent of patients without pre-existing glaucoma needed glaucoma therapy after UGH syndrome resolution. This study is limited by its retrospective nature. Using two control groups is a strength of this study.
Uveitis‐Glaucoma‐Hyphaemia syndrome retrospective case-control study
Reviewed by Kareem Waleed Alsaffarini
Seventy‐one cases of uveitis‐glaucoma‐hyphaema syndrome.
