The authors assessed the ease and utility of ultra-widefield fundus autofluorescence (UWF-FAF) in detecting suspected inherited retinal disease in children who were difficult to examine. They aimed to assess the sensitivity of UWF-FAF and UWF-CF (colour fundus) photography and clinical examination in diagnosing the disease. This was a retrospective study of 124 eyes of 62 children from 2015-2018. Assessment was 10 minutes per patient for both eyes. Children were aged a mean of 5.6 years (1-13) and there were 30 males, 32 females. Twelve eyes were excluded due to poor fixation because of nystagmus. All had reduced visual acuity <0.58 logMAR. Findings included hyper-autofluorescent ring, retinal flecks, retinal atrophy, disease present and disease absent. FAF showed high sensitivity in detecting pathological findings characteristic of inherited retinal dystrophies compared to CF and clinical examination. FAF had higher diagnostic yield; perhaps because there is more time to view and consider the images in detail. The authors recommend UWF-FAF as non-invasive, high speed and high resolution imaging system.
Ultra-widefield fundus autofluorescence
Reviewed by Fiona Rowe
Ultra-wide-field fundus autofluorescence for the detection of inherited retinal disease in difficult-to-examine children.
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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