In this meta-analysis, the authors looked at 24 retrospective studies to determine the incidence of sympathetic ophthalmia following open globe injury amongst adult and paediatric populations. The year of publication of studies included ranged from 1972-2019, and with broad search terms used it is likely that all relevant publications were identified. The authors also carried out a risk of bias and study quality assessment and calculated a separate incidence for the 10 least biased studies. This analysis showed similar incidence with overlapping confidence intervals when compared to incidence over all 24 studies. The authors found an incidence proportion of 0.19% and an incidence rate of 33 per 100,000 person-years of sympathetic ophthalmia in open globe injuries, which is likely higher than previously thought.
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