This study reports the surgical experience with superior or inferior rectus resection to correct vertical strabismus associated with thyroid eye disease (TED). The study included eight female euthyroid patients (nine muscles) with mean age at surgery of 65±8.9 years and mean follow-up of 57±41 months. Surgery involved five superior rectus and four inferior rectus resections. Mean resection for inferior rectus was 3.5±1mm and for superior rectus was 5.2±1.5mm. Preoperative vertical deviation at near fixation was 14.2 ±8.4PD reducing to 4.8±3.7PD by one month, 5.7±4.9PD by four months and 6.7±6.7PD by final follow-up. At distance preoperative angle was 15.8±8.8PD reducing to 3.9 ±3.9 by one month, 6.7±7PD by four months and 7.4±8.8PD by final follow-up. The authors conclude that in carefully selected patients, vertical rectus resection may be considered as a surgical option in treatment of large angle strabismus causing significant diplopia and obvious ocular misalignment.