The aim of this study is to evaluate retinal nerve fibre layer (RNFL) thickness changes in children with migraine compared to healthy controls and analyse RNFL changes dependent on type of migraine. This was an observation case control study of 18 children, nine of which had migraine without aura. Mean age was 13.8 years ±2.9 in patients and 13.4 years ±2.5 in controls. Mean duration of migraine was 19.3 months for those with aura and 43.8 months for those without aura. For RNFL, there was no difference overall for patients vs. controls. However, those with aura had statistically significant differences in temporal and inferotemporal RNFL thickness compared to those without aura. Negative correlations were found for the number of episodes per month and RNFL thickness in the nasal-superior quadrant. Positive correlations were found for duration and global RNFL thickness. Generally, results showed that migraine with aura had thinner RNFL in some sectors and RNFL thickness correlates with episode frequency. The authors discuss the potential to use RNFL thickness measures as a possible objective value to follow-up migraine over time for evolution and to assess effects of treatment.
Retinal nerve fibre layer thickness in migraine
Reviewed by Fiona Rowe
Retinal nerve fibre layer analysis in children with migraine with and without aura using optical coherence tomography: a case-control study.
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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