This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.  Read our Cookies Policy.
Close
Eye News
  • Features
    • Close
    • Features
    • Allied Professions
    • Humanitarian
    • Interviews
    • AI & Oculomics
    • Ophthalmology
    • Optometry
    • Podcast videos
    • Supplements
  • Education
    • Close
    • Education
    • Learning Curve
    • Quiz
    • Top Tips
    • Trainees
    • Medico-Legal
    • The Truth Behind The Headlines
    • Case Reports
    • Pete's Bogus Journey
  • Reviews
    • Close
    • Reviews
    • Book Reviews
    • Journal Reviews
    • What's trending?
    • Tech Reviews
    • My Top Five
    • The Culture Section
  • Events
  • News
  • Product Guide
  • Industry News
  • Contact us
    • Close
    • Contact us
    • Write for Eye News
  • Home
  • Reviews
  • Journal Reviews
  • Retinal ischaemia on OCTA and diabetic retinopathy grade

Retinal ischaemia on OCTA and diabetic retinopathy grade
Reviewed by Saruban Pasu

1 April 2020 | Saruban Pasu | EYE - Vitreo-Retinal
Share This

The authors quite rightly point out that quantification of retinal ischaemia has the potential to serve as a biomarker for diabetic retinopathy disease progression. They set out to investigate the relationship between area of ischaemia on a swept source OCTA and severity of diabetic retinopathy. A combination of a manual and automated method of non-perfusion area calculation was used when analysing the OCTA images. Seventy-three eyes were included for analysis. Of the 73 eyes, 28 eyes had no clinical evidence of retinopathy, nine eyes were graded as mild non-proliferative diabetic retinopathy (NPDR), 10 eyes as moderate NPDR, five eyes as severe NPDR, and 21 eyes as proliferative diabetic retinopathy (PDR). Diabetic macular oedema was present in one of the 10 eyes with moderate NPDR, two of the five eyes with severe NPDR, and eight of the 21 eyes with PDR. In eyes without DR, the mean percentage area of non-perfusion was 0.1%, in the NPDR eyes (mild, moderate, and severe), the mean percentage area was 2.1% in the PDR eyes, and the mean percentage area was 8.5%. The percentage of area of ischaemia increased in a statistically significant manner from eyes without DR, to eyes with NPDR, to eyes with PDR. Within the PDR group, the mean percentage area of non-perfusion was 12.5% when macular oedema (ME) was present, compared with 7.5% when ME was absent. This difference was not found to be statistically significant. In keeping with results from previous OCTA and FFA studies, this paper showed that there is a statistically significant increase in the percentage of non-perfusion area as DR severity increases.

Quantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography.
Alibhai Y, De Pretto L, Moult E, et al.
RETINA
2020;40(3):412-20.
Share This
CONTRIBUTOR
Saruban Pasu

Moorfields Eye Hospital, London, UK.

View Full Profile
Specialty
  • EYE - Cataract
  • EYE - Cornea
  • EYE - General
  • EYE - Glaucoma
  • EYE - Neuro-ophthalmology
  • EYE - Oculoplastic
  • EYE - Oncology
  • EYE - Orbit
  • EYE - Paediatrics
  • EYE - Pathology
  • EYE - Refractive
  • EYE - Strabismus
  • EYE - Vitreo-Retinal
Archive
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013

Top Of Page

9 Gayfield Square, 
Edinburgh EH1 3NT, UK.

Call: +44 (0)131 557 4184
www.pinpoint-scotland.com

WEBSITE DETAILS
  • Cookie Policy
  • Data Protection Notice
  • Privacy Policy
  • Terms and Conditions
ABOUT US
  • Who we are
  • Register
  • Contact us
  • Contributors
  • Company Awards
DIGITAL ISSUES/GUIDELINES
  • Digital issues - Library
  • Supplements - Library
  • Guidelines
Accreditations
IPSO_FLAG_TEAL 2025.png cpdcertified.png

Pinpoint Scotland Ltd (Registered in Scotland No. SC068684) | © 2025 - Website by Gecko Agency