The authors aimed to compare refractive results of intravitreal bevacizumab (IVB) injection in premature neonates with retinopathy of prematurity (ROP) versus infants with spontaneous regression of ROP. The study included 87 infants (174 eyes). Group 1 included 38 infants (76 eyes) with type 1 ROP; 10 with zone I and 28 with zone II posterior. Group 2 included 49 infants (98 eyes) with type 2 ROP; 2 zone I, 32 zone II, 15 zone III which spontaneously regressed with no anatomical sequelae at one year adjusted age. There was no significant difference for right versus left eyes. Therefore, right eye results were analysed. At one year adjusted age, mean spherical equivalent refractive error was not significant between groups. Group 1 had a significant correlation for birth weight and spherical equivalent value at one year adjusted age. This was not found for group 2. The authors recommend further studies with longer follow-up to evaluate the effects of IVB on the emmetropisation process inclusive of biometry assessment.
Refraction results in ROP with and without IVB
Reviewed by Fiona Rowe
Refractive outcome of intravitreal bevacizumab injection in comparison to spontaneous regression of retinopathy of prematurity (ROP).
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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