This systemic review and meta-analysis investigated the incidence and type of ocular injuries reported in adult critical care from both prone and supine patients between January 1990 and July 2020. They reviewed 11 randomised controlled trials. In three trials, 28 events were recorded. There were no events recorded in the other eight trials. The found that the rate of eye injury was 15 events in 1158 patients (1.3%) and 13 events in 1089 patients (1.19%). Most of these events (24/28) were related to eyelid oedema. Meta-analysis demonstrated that there was no significant difference between the proned and supine group. There needs to be further investigation into the long-term effects of proning especially considering the COVID-19 pandemic where it has been used widely.