This study aimed to analyse the stability and progression of higher degrees of myopic anisometropic in children. This retrospective study included 63 children meeting the inclusion criteria. Mean age at initial visit was 4.3 years ±2. There were 51% males and mean follow-up was 5.6±0.9 years. The more ametropic eye grew in a regular manner during the first two years followed by a rapid decrease in the rate of growth so that refractive changes were minimal after four years of age. The less ametropic eye showed only a small increase in myopia during follow-up. Anisometropia difference between eyes increased gradually during the first two years, then remained stable during follow-up. Large degrees of anisometropia at an early age had little influence on progression of myopia after four years and up to 13 years suggesting that large degrees of anisometropic are not a risk factor for the progression of myopia after four years of age. The authors conclude that high anisometropic myopia progresses rapidly in the first few years before becoming stable.