This retrospective cohort study was completed to help identify potential risk factors for developing persistent anterior uveitis (PAU) following uncomplicated cataract surgery in patients with no prior history of uveitis or autoimmune disease. A total of 3013 eyes (2019 patients) who underwent cataract extraction between January 2014 and December 2016 were reviewed. Sixty-one eyes (2%) developed PAU but had no prior history of uveitis or autoimmune disease. It was found that African Americans were more likely to develop PAU compared to Caucasians. However, these patients did not have worse visual acuity (VA) than those without PAU. In addition, compared to other races with PAU, African Americans with PAU did not have worse VA or intraocular pressure (IOP). Age, sex, surgery length and cumulative dissipated energy (CDE) were not risk factors for PAU. This study is the first of its kind to suggest race as a risk factor for PAU post cataract surgery although the cause for this is not clear and further studies are required.