This study aimed to compare the clinical outcomes following the implantation of an extended depth of focus small-aperture intraocular lens (IOL) (IC-8; AcuFocus, Irvine, CA) for presbyopia correction when implanted monocularly or binocularly. Visual outcomes, defocus curve, patient satisfaction, and visual symptoms during a six-month follow-up were evaluated in 11 patients (contralateral group) implanted monocularly with this IOL and with an aspheric monofocal IOL in the fellow eye (myopic target) and six patients (bilateral group) implanted bilaterally with the IC-8 IOL (dominant eye with plano target, fellow eye with myopic target). Bilateral implantation of the IC-8 IOL resulted in an extended range of focus, with better intermediate and near vision. Monocular implantation of the IC-8 IOL resulted in a significantly higher overall satisfaction score and lower halo score. The authors found that bilateral implantation of the IC-8 IOL resulted in an extended range of focus, with better intermediate and near vision than monocular implantation of this IOL. Patient satisfaction was high in eyes with monocular implantation, however lower overall satisfaction and higher scores for halos were found in eyes with binocular implantation. Future studies are necessary with greater patient numbers and longer follow-up periods.